Suppression of the development of uterine adenomyosis by danazol treatment in mice

T Singtripop, Tippawan Singtripop, Singtripop T, Takao Mori, T Mori, Mori T, Shinobu Sakamoto, Sakamoto S, S. Sakamoto, Shuji Sassa, Sassa S, S Sassa, Min Kyun Park, Park MK, M K Park, Kawashima S, Seiichiro Kawashima, S Kawashima
Life sciences · 1992 · vol. 51(14) , pp. 1119–1125 · doi:10.1016/0024-3205(92)90513-o · PMID:1518375 · W1967782334
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Danazol treatment was found to suppress the development of uterine adenomyosis in a mouse model.

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Abstract

Inhibitory effects of danazol, an isoxazol derivative of synthetic steroid 17 alpha-ethinyl-testosterone, on the development of uterine adenomyosis, a pathological disorder of endometrial tissue defined as the presence of endometrial glands and stroma in the myometrium, were investigated in mice of SHN strain. Mice treated with 0.5 microgram danazol for 5 weeks during 4-9 weeks of age and killed at 21 weeks of age showed significantly lower incidence of the spontaneous development of adenomyosis than the age-matched intact control mice. The inhibitory effects of danazol were also evident in mice bearing pituitary isografts which were effective in inducing an early and a high incidence of adenomyosis. Furthermore, the treatment with danazol resulted in the decrease of serum levels of luteinizing hormone (LH) and prolactin (PRL) associated with hypofunction of ovaries and persistent diestrus. These results support the usefulness of danazol for the clinical treatment of gynecological disorders except for hypofunction of ovaries.

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Condition tags

endometriosisadenomyosis

MeSH descriptors

Danazol Endometriosis Animals Danazol Endometriosis Endometriosis Estrus Estrus Female Follicle Stimulating Hormone Follicle Stimulating Hormone Luteinizing Hormone Luteinizing Hormone Mice Ovary Ovary Ovary Pituitary Gland Pituitary Gland Pituitary Gland, Anterior

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Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

References (24)

Cited by (16)

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