The effect of danazol in the treatment of chronic cystic mastitis.
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Danazol treatment of 40 chronic cystic mastitis patients at 400 mg daily resulted in marked symptom improvement in 87.5%, with mild weight gain as the major side effect and no significant changes in hormone levels.
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Abstract
Danazol in a dose of 400 mg daily was administrated to 40 patients with chronic cystic mastitis and resulted in a marded improvement in both objective and subjective symptoms in 87.5% of the patients studied. Three patients showed partial relief of symptoms and 1 patient showed no improvement after 1 month of treatment at which time she withdrew from the study. One patient had a worsening of her condition and was withdrawn from the study after 3.5 months of therapy. Nineteen of the 40 patients in the study had a secondary diagnosis of pelvic endometriosis confirmed histologically, and all these patients showed a marked improvement of symptoms during the Danazol treatment. Patients developed amenorrhea after 3 to 4 months of Danazol therapy, and symptoms such as dysmenorrhea, premenstrual pelvic pain, and tension abated at the same time. A mild, but well-tolerated weight gain was the major side effect of Danazol administration. No significant changes in the levels of plasma E1, E2, FSH, LH, or progesterone could be demonstrated in specimens drawn from 11 patients before and during the course of Danazol administration.
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Cited by (29)
- Danazol 2022
- Physicochemical, in silico and in vivo evaluation of a danazol–β-cyclodextrin complex 2007
- Danazol-β-cyclodextrin binary system: A potential application in emergency contraception by the oral route 2007
- Effects of Danazol on endometrial DNA synthesis in rats 1993
- Effects of danazol on DNA synthesis in rat prostate 1993
- The effect of danazol on tumour control and weight loss in patients on tamoxifen therapy for advanced breast cancer: A randomised double-blind placebo controlled trial 1993
- Suppression of the development of uterine adenomyosis by danazol treatment in mice 1992
- Treatment of laparoscopically confirmed endometriosis with danazol 1989
- Inhibitory effects of danazol on steroidogenesis in cultured human granulosa cells 1986
- Long‐Term Danazol Treatment for an Adolescent Girl with Aplastic Anemia 1986
- Effects of danazol on steroidogenesis and gonadotropic responsiveness in isolated human preovulatory follicular cells 1986
- Danazol treatment of severely symptomatic fibrocystic breast disease and long‐term follow‐up—the Hjørring project 1984
- Treatment of recurrent cyclical mastodynia in patients with fibrocystic breast disease 1984
- THE INTERACTION OF HUMAN ENDOMETRIAL AND MYOMETRIAL STEROID RECEPTORS WITH DANAZOL 1983
- Fibrocystic breast disease 1982
- Effects of danazol on gonadal steroidogenesis in patients with a complete form of testicular feminization 1982
- CONTROLLED TRIAL OF THE ANTIGONADOTROPIN DANAZOL IN PAINFUL NODULAR BENIGN BREAST DISEASE 1982
- Androgen uptake in the female reproductive system of a nonhuman primate 1981
- Transient Adrenogenital Syndrome due to Exposure to Danazol in Utero 1981
- Evidence that danazol inhibits gonadotropin-induced ovarian steroidogenesis at a point distal to gonadotropin-receptor interaction and adenosine 3′,5′ cyclic monophosphate formation 1980
- Danazol for benign breast disease 1980
- Danazol in the Treatment of Gynaecomastia 1980
- Danazol in the Treatment of Mammary Dysplasia 1980
- Danazol Suppresses Luteal Function in Vitro and in Vivo 1980
- The Treatment of Benign Breast Disease with Danazol 1980
- Effect of danazol on estradiol-17β and progesterone secretion by porcine ovarian cells in vitro 1979
- THE EFFECT OF DANAZOL ON MENORRHAGIA, COAGULATION MECHANISMS, HAEMATOLOGICAL INDICES AND BODY WEIGHT 1979
- Treatment of Severe Cyclical Mastalgia 1979
- Danazol Inhibits Steroidogenesis 1977
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- europepmc
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- openalex
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- pubmed
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