Evidence that danazol inhibits gonadotropin-induced ovarian steroidogenesis at a point distal to gonadotropin-receptor interaction and adenosine 3′,5′ cyclic monophosphate formation
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Danazol was found to inhibit gonadotropin-induced steroidogenesis in the ovary at a step after gonadotropin receptors are activated and cAMP is produced.
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Abstract
The action of danazol on 125I-human chorionic gonadotropin (hCG) binding, gonadotropin-stimulated adenosine 3',5' cyclic monophosphate (cAMP) accumulation and progesterone production has been investigated in luteinized rat ovaries. Preincubation of luteal cells for short periods of time with increasing concentrations of danazol caused a significant inhibition of gonadotropin-stimulated steroidogenesis. The inhibitory effect of danazol was both concentration and time dependent. Danazol also reduced progesterone production in response to cholera enterotoxin and 8 bromo-adenosine-cAMP, but it had no effect on hCG, luteinizing hormone, and cholera enterotoxin stimulated cAMP formation. Similarly danazol did not affect 125I-hCG binding as assessed by the equilibrium dissociation constant (Kd) and number of hormone-binding sites on the luteal cell surface. These results suggest that in intact luteal cells danazol inhibits steroidogenesis at a point distal to hormone-receptor interaction and cAMP formation.
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Cited by (24)
- Danazol 2022
- Thermoregulatory and endocrine effects of a low dose of danazol in postmenopausal women: Interaction with the effect of naloxone 1991
- Effects of an androgenic derivative on pre-established mammary tumours chemically induced in the rat 1991
- Inhibition of Rat Ovarian 3.BETA.-Hydroxysteroid Dehydrogenase (3.BETA.-HSD), 17.ALPHA.-Hydroxylase and 17, 20 Lyase by Progestins and Danazol. 1989
- Danazol concentrations in human ovarian follicular fluid and their relationship to simultaneous serum concentrations 1988
- Plasma and peritoneal fluid levels of CA 125 in women with endometriosis 1988
- Endometriosis 1987
- Endocrine Therapy In Primary and Advanced Breast Cancer 1986
- Danazol inhibits steroidogenesis by the human ovary in vivo 1986
- Direct biphasic effects of danazol on gonadotropin-dependent differentiation of cultured rat granulosa cells 1986
- Inhibition of gonadotropin-releasing hormone receptors in rat anterior pituitary monolayer cell cultures by danazol 1986
- Inhibitory effects of danazol on steroidogenesis in cultured human granulosa cells 1986
- Effects of danazol on steroidogenesis and gonadotropic responsiveness in isolated human preovulatory follicular cells 1986
- Changes in the shbg concentration during danazol treatment 1984
- In vitro effect of danazol on steroidogenesis in developing human follicles 1984
- Endocrine effects of danazol in the treatment of endometriosis 1984
- Danazol treatment of severely symptomatic fibrocystic breast disease and long‐term follow‐up—the Hjørring project 1984
- Influence of danazol on cytoplasmic and nuclear estrogen binding capacity in the uterus 1983
- Effects of danazol on gonadal steroidogenesis in patients with a complete form of testicular feminization 1982
- Danazol: Endocrine consequences in healthy women 1981
- Changes of Prolactin Secretion Following Long-Term Danazol Application 1981
- In Vitro Effect of Danazol on Luteinizing Hormone-Releasing Hormone-Stimulated Luteinizing Hormone Release in Rat Anterior Pituitary Cell Cultures in Vitro * 1981
- Endometriosis--continuing conundrum. 1980
- Endometriosis—continuing conundrum 1980
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