CONTROLLED TRIAL OF THE ANTIGONADOTROPIN DANAZOL IN PAINFUL NODULAR BENIGN BREAST DISEASE
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This controlled trial investigated the efficacy of the antigonadotropin danazol in treating painful nodular benign breast disease.
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Abstract
In a double-blind crossover study of the effects of the antigonadotropin danazol on pain and nodularity in 28 women with cyclical mastalgia danazol was given at doses of 200 mg/day and 400 mg/day, and the responses were assessed both subjectively and objectively. Danazol caused a significant and progressive decrease in breast pain and nodularity when compared with placebo. Symptoms responded more quickly with the 400 mg/day dose of danazol than with the 200 mg dose, but the larger dose also caused greater side-effects. Danazol is a useful addition to the range of antihormones that can be used to suppress the symptoms of severe hormone-related benign breast disease.
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Cited by (20)
- A Comparative Study of Danazol alone with Danazol Combined with Evening Primrose Oil in the Treatment of Fibrocystic Breast Disease 2022
- Mastalgia: A narrative literature review of current understanding and management 2018
- Evidence-based management of Mastalgia: A meta-analysis of randomised trials 2007
- Evaluation and Management of Breast Pain 2004
- 2. BENIGN BREAST DISEASE 2001
- Drug Therapy of Mastalgia 1994
- Gestrinone in mastalgia: A randomized double blind placebo controlled trial 1994
- Multicentre study of gestrinone in cyclical breast pain FRIEDOLF PETERS 1992
- Progesterone receptor induction by danazol in cultured cancer cells and the rat uterus 1992
- Mastalgia refractory to drug treatment 1990
- Management of breast pain and nodularity 1989
- Cyclical mastopathy: A critical review of therapy 1988
- The Treatment of Symptomatic Benign Breast Disease with Danazol 1988
- Reduction of Cysts in Fibrocystic Breast Disease during and after Danazol Treatment 1986
- Treatment of cyclical mastalgia with low dose short term danazol 1986
- CLINICAL EXPERIENCE OF DRUG TREATMENTS FOR MASTALGIA 1985
- Endocrine effects of danazol in the treatment of endometriosis 1984
- Danazol treatment of severely symptomatic fibrocystic breast disease and long‐term follow‐up—the Hjørring project 1984
- Treatment of recurrent cyclical mastodynia in patients with fibrocystic breast disease 1984
- Vitamin D metabolites and analogues, diphosphonates, danazol, and bromocriptine. 1983
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