A Comparative Study of Danazol alone with Danazol Combined with Evening Primrose Oil in the Treatment of Fibrocystic Breast Disease

Introduction: Mastalgia was described in the medical literature as early as 1829 and is the most common complaint among women of child bearing age. Breast pain among women with or without lump is a common complaint and a cause of significant anxiety and fear of breast cancer. Objective: To assess the Danazol alone with Danazol combined with Evening Primrose Oil in the treatment of Fibrocystic Breast Disease. Methods: The study was conducted in the department of surgery, Shaheed Ziaur Rahman Medical College Hospital, Bogura, Bangladesh from January to July 2022. A total 110 women were selected an initial clinical assessment and breast imaging and had maintained a proper breast pain chart. The registers of the Surgery outdoor Patient department were crosschecked and the list of all females presenting with mastalgia treated with Danazol and Evening Primrose Oil in dosage mentioned for this study was made. A total 100 women were selected an initial clinical assessment and breast imaging and had maintained a proper breast pain chart. Results: The most common age group in cyclical mastalgia was 18-25 years involving 73.2% patients while in non-cyclical mastalgia the most common age group was 26-35 years involving 42.4% patients. 24.7 years and 30.3 years was the mean age for cyclical and noncyclical mastalgia. In our study overall mastalgia showed better useful response with Danazol (59.2%) than with EPO (41.1%) and this difference was statistically significant (Fisher’s exact test 2-tailed p value 0.05). Cyclical mastalgia showed better observed response with Danazol (68.4%) than EPO (46.2%), this difference coming out to be statistically significant, Fisher’s exact test 2- tailed p value 0.02. Non-cyclical mastalgia showed slightly better observed response with Danazol (33.3%) than EPO (27.7%), this difference coming out to be statistically insignificant, Fisher’s exact test 2-tailed p value 0.40. Conclusion: Mastalgia is more common in females in their reproductive ...