Danazol suppresses luteal function in vitro and in vivo

Keith Henderson, K. M. Henderson, Benjamin K. Tsang, B K Tsang
Fertility and sterility · 1980 · vol. 33(5) , pp. 550–556 · doi:10.1016/s0015-0282(16)44722-9 · PMID:7371884 · W2464919422
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Danazol was found to suppress luteal function both in laboratory experiments and in living organisms.

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Abstract

Danazol inhibited chorionic gonadotropin-stimulated progesterone production by pregnant rat luteal cells in vitro in a dose-dependent fashion. Spectral studies indicated that the inhibition was a consequence of danazol's interfering with the functioning of mitochondrial cytochrome P-450, an essential component of the enzyme system involved in progesterone biosynthesis. Danazol also suppressed luteal function in vivo, serum levels of progesterone being reduced by 50% to 70% when danazol (50 mg/kg) was administered thrice daily to rats from days 10 to 15 of pregnancy. Since danazol (30 microM) also inhibited progesterone production by human luteal cells in vitro and was dominant to the luteotrophic action of chorionic gonadotropin, it is suggested that danazol may have some potential as an interceptive agent in humans.

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MeSH descriptors

Chorionic Gonadotropin Corpus Luteum Danazol Pregnadienes Animals Binding Sites Chorionic Gonadotropin Corpus Luteum Cytochrome P-450 Enzyme System Cytochrome P-450 Enzyme System Danazol Dose-Response Relationship, Drug Female Humans Male Microsomes Microsomes Pregnadienes Pregnancy Progesterone

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