Structural and functional regression of polycystic ovaries by danazol

Shailaja G. Raj; S G Raj; Madhwa H.G. Raj; M H Raj; L M Talbert; Luther M. Talbert; Ruth Dy; R C Dy

doi:10.1016/s0015-0282(16)45743-2

Structural and functional regression of polycystic ovaries by danazol

Shailaja G. Raj, S G Raj, Madhwa H.G. Raj, M H Raj, L M Talbert, Luther M. Talbert, Ruth Dy, R C Dy

Fertility and sterility · 1981 · vol. 36(3) , pp. 392–395 · doi:10.1016/s0015-0282(16)45743-2 · PMID:7197232 · W86841406

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This study investigated the effects of danazol on polycystic ovaries, observing structural and functional regression.

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Abstract

The effects of danazol on ovarian steroidogenesis and follicular size was studied in androgen-sterilized rats bearing polycystic ovaries. Daily treatment with 4 or 20 mg of the drug caused a reduction in ovarian weight and regression of cystic follicles. Serum levels of luteinizing hormone (LH), testosterone, and estrogen were significantly decreased. The persistent estrus smears were changed to diestrus, indicating inhibition of estrogenic activity.

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MeSH descriptors

Danazol Polycystic Ovary Syndrome Pregnadienes Animals Danazol Estrogens Estrogens Estrus Estrus Female Luteinizing Hormone Luteinizing Hormone Organ Size Organ Size Ovary Ovary Polycystic Ovary Syndrome Pregnadienes Pregnancy Rats

Citation neighborhood (sparse)

Too few in-corpus citations on either side for a chart; here are the lists.

Cites (4)

References (15)

Danazol Inhibits Steroidogenesis via openalex
Danazol inhibits steroidogenesis in the rat testis in vitro via openalex
Danazol suppresses luteal function in vitro and in vivo via openalex
Pituitary and testicular function studies. I. Experience with a new gonadal inhibitor, 17-alpha-pregn-4-en-20-yno-(2,3-d)isoxazol-17-ol (Danazol) via openalex
W6717743593 via openalex
W6721741369 via openalex
doi:10.1016/s0015-0282(16)34681-7 via openalex
doi:10.1016/0002-9378(63)90430-7 via openalex
doi:10.1097/00006254-197710000-00017 via openalex
doi:10.1210/endo-68-1-68 via openalex
doi:10.1210/jcem-22-3-325 via openalex
doi:10.1530/acta.0.0490453 via openalex
doi:10.1095/biolreprod17.5.676 via openalex
doi:10.1016/b978-0-12-379260-0.50041-8 via openalex
doi:10.1210/jcem-30-4-435 via openalex

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[1] Danazol Inhibits Steroidogenesis 1977

[2] Pituitary and testicular function studies. I. Experience with a new gonadal inhibitor, 17-alpha-pregn-4-en-20-yno-(2,3-d)isoxazol-17-ol (Danazol) 1971

[3] Danazol inhibits steroidogenesis in the rat testis in vitro 1977

[4] Danazol suppresses luteal function in vitro and in vivo 1980