Danazol

Letters and Corrections1 August 1982DanazolROBERT L. BARBIERI, M.D.ROBERT L. BARBIERI, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-97-2-286_1 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: The recent review of danazol by Madanes and Farber (1) is an excellent summary of the drug's properties. However, there are a few substantive errors that need correction.Madanes and Farber state than danazol inhibits adrenal 16α-hydroxylase. The paper (2) they cite to support this statement does not examine the effects of danazol on 16α-hydroxylase, and other unpublished reports have shown that danazol does not inhibit 16α-hydyroxylase. The authors state that danazol inhibits microsomal and mitochondrial cytochrome P-450 in cultured adrenal tissue. In fact, the experiments cited were done on isolated mitochondrial and microsomal fractions in vitro...References1. MADANESFARBER AM. Danazol. Ann Intern Med. 1982;96:625-30. LinkGoogle Scholar2. BARBIERIOSATHANONDHCANICKSTILLMANRYAN RRJRK. Danazol inhibits human adrenal 21- and 11-hydroxylation in vitro. Steroids. 1980;35:251-63. CrossrefMedlineGoogle Scholar3. HENDERSENTSANG KB. Danazol suppresses luteal function in vitro and in vivo. Fertil Steril. 1980;33:550-6. CrossrefMedlineGoogle Scholar4. BARBIERIRYAN RK. Danazol: endocrine pharmacology and therapeutic applications. Am J Obstet Gynecol. 1981;141:453-63. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Massachusetts General Hospital Boston, MA 02114 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByAdditive hormonal therapy in women with advanced breast cancer 1 August 1982Volume 97, Issue 2Page: 286-286KeywordsDrugs Issue Published: 1 August 1982 PDF DownloadLoading ...