Danazol as a Luteolytic Agent

Anne Colston Wentz, Karan C. Sapp
In: Fertility and Sterility · 1978 · vol. 29(1) , pp. 23–25 · doi:10.1016/s0015-0282(16)43030-x · W2284359111
article OA: closed CC0 ⤵ 4 in-corpus citations
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This paper investigates the luteolytic properties of danazol, a synthetic steroid, and its potential application in terminating the luteal phase of the menstrual cycle.

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Abstract

Danazol, a synthetic 2,3-isoxazol derivative of 17 alpha-ethinyltestosterone, was administered to healthy nonpregnant volunteers to determine wheter a luteolytic effect could be detected by observation of cycle length, duration of the luteal rise, and luteal steroidogenesis. Danazol administration resulted in a decreased duration of the luteal rise and a decrease in progesterone output in three of four subjects, but no decrease in total cycle length. The administration of human chorionic gonadotropin during danazol administration increased progesterone output. Therefore, danazol would be unlikely to be effective as a luteolytic contraceptive agent.

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