Ultrastructural Changes in Endometriotic Tissue During Danazol Treatment

Karl-Werner Schweppe, K W Schweppe, Schweppe KW, W. Paul Dmowski, W P Dmowski, Dmowski WP, Wynn RM, Ralph M. Wynn, R M Wynn
Fertility and sterility · 1981 · vol. 36(1) , pp. 20–26 · doi:10.1016/s0015-0282(16)45612-8 · PMID:7250403 · W2415749469
article OA: closed CC0 ⤵ 25 in-corpus citations
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This study investigated the ultrastructural changes in endometriotic tissue following danazol treatment.

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Abstract

Electron microscopic examinations were carried out on 29 representative endometriotic glands obtained from 16 biopsies. Patients with endometriosis diagnosed by laparoscopy and confirmed by laparoscopic biopsy prior to hormonal treatment received danazol, 800 mg daily. The tissue samples were obtained after 2, 4, and 6 months of usage of the drug to study the ultrastructural effect of this treatment. The glandular epithelium appeared to be arrested in what looked like the late proliferative stage of the normal menstrual cycle. The ciliated cells remained unchanged for the most part. The findings were correlated with possible effects of danazol on the target tissue, but caution is required in the interpretation of ultrastructural effects of steroids until detailed knowledge of the metabolic pathways is available.

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Condition tags

endometriosis

MeSH descriptors

Danazol Endometriosis Endometrium Ovarian Neoplasms Pregnadienes Adult Danazol Endometriosis Endometriosis Endometrium Female Humans Ovarian Neoplasms Ovarian Neoplasms Pregnadienes

Citation neighborhood

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

References (24)

Cited by (25)

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