Ultrastructural changes in endometriotic tissue during danazol treatment

Karl-Werner Schweppe, K W Schweppe, Schweppe KW, W. Paul Dmowski, W P Dmowski, Dmowski WP, Wynn RM, Ralph M. Wynn, R M Wynn
Fertility and sterility · 1981 · vol. 36(1) , pp. 20–26 · doi:10.1016/s0015-0282(16)45612-8 · PMID:7250403 · W2415749469
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This study investigated the ultrastructural changes in endometriotic tissue following danazol treatment.

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Abstract

Electron microscopic examinations were carried out on 29 representative endometriotic glands obtained from 16 biopsies. Patients with endometriosis diagnosed by laparoscopy and confirmed by laparoscopic biopsy prior to hormonal treatment received danazol, 800 mg daily. The tissue samples were obtained after 2, 4, and 6 months of usage of the drug to study the ultrastructural effect of this treatment. The glandular epithelium appeared to be arrested in what looked like the late proliferative stage of the normal menstrual cycle. The ciliated cells remained unchanged for the most part. The findings were correlated with possible effects of danazol on the target tissue, but caution is required in the interpretation of ultrastructural effects of steroids until detailed knowledge of the metabolic pathways is available.

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Condition tags

endometriosis

MeSH descriptors

Danazol Endometriosis Endometrium Ovarian Neoplasms Pregnadienes Adult Adult Danazol Danazol Endometriosis Endometriosis Endometriosis Endometrium Endometrium Female Female Humans Humans Ovarian Neoplasms Ovarian Neoplasms

Citation neighborhood (2-hop)

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. Outer rings show 2-hop neighbours — papers reached through the immediate citers/citees. [ collapse to 1-hop ]

References (24)

Cited by (24)

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