Is There a Rationale for GnRH Analogue Therapy in Endometriosis?

In: GnRH Analogues in Reproduction and Gynecology · 1990 · pp. 1–6 · doi:10.1007/978-94-009-0721-8_1 · W1596415044
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This paper discusses diagnostic criteria and evaluation of medical therapy response for endometriosis, a common gynecological disease with ongoing debate about its pathogenesis and treatment.

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This chapter discusses the rationale for GnRH analogue therapy in endometriosis by reviewing criteria used to diagnose endometriosis and to evaluate response to medical therapy, alongside ongoing controversies in the field’s understanding of pathogenesis and pathophysiology. It synthesizes prior evidence and frameworks for assessing therapeutic effects, emphasizing how outcomes are judged in studies of medical treatments. The main limitation is that, as a narrative review/chapter, it does not present new primary clinical data and instead highlights conceptual and methodological issues in evaluating treatments. Relevance to endometriosis: the paper is explicitly about endometriosis and the rationale for GnRH analogue therapy, including how diagnosis and treatment response evaluation criteria are discussed in that context.

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Abstract

Although endometriosis is considered as the most common benign gynaecological disease in women during their reproductive years and despite many hundreds of articles having been written on the subject, much controversy remains regarding its pathogenesis, pathophysiology and therapy. In this paper the criteria for diagnosis and evaluation of response to medical therapy will be discussed. Preview Unable to display preview. Download preview PDF. Similar content being viewed by others

References

Sampson, JA (1921). Perforating hemorrhagic (chocolate) cysts of the ovary, their importance and especially their relation of pelvic adenomas of the endometrial type. Arch Surg, 3, 245 Sampson, JA (1924). Benign and malignant implants in the peritoneal cavity and their relation to certain ovarian tumors. Surg Gynecol Obstet, 32, 287 Sampson, JA (1927). Peritoneal endometriosis due to menstrual dissemination of endometrial tissue into the peritoneal cavity. Am J Obstet Gynecol, 14, 422 Chatman, DL (1981). Pelvic peritoneal defects and endometriosis: Allen-Masters syndrome revisited. Fertil Steril, 36, 751 Chatman, DL and Zbella, EA (1986). Pelvic peritoneal defects and endometriosis: further observations. Fertil Steril, 47, 711 Redwine, DBA (1985). Atypical endometriosis. In Prog Ann Meet Am Fert Soc, 64 (Abstract) Jansen, RPS and Russell, P (1986). Nonpigmented endometriosis: clinical, laparoscopic and pathologic definition. Am J Obstet Gynecol, 155, 1154 Vasquez, G, Cornillie, F and Brosens, IA (1984). Peritoneal endometriosis: scanning electron microscopy and histology of minimal pelvic endometriotic lesions. Fertil Steril, 42, 496 Murphy, AA, Green, WR, Bobbie, D, dela Cruz, ZC and Rock, JA (1987). Unsuspected endometriosis documented by scanning electron microscopy in visually normal peritoneum. Fertil Steril, 46, 522 Vernon, MW, Beard, JS, Graves, K and Wilson, EA (1986). Classification of endometriotic implants by morphologic appearance and capacity to synthesize prostaglandin. Fertil Steril, 46, 801 Cornillie, FJ, Brosens, IA, Vasquez, G and Riphagen, I (1986). Histologic and ultrastructural changes in human endometriotic implants treated with antiprogesterone steroid ethylnorgestrinone (gestrinone) during 2 months. Int J Gynecol Path, 5, 95 Brosens, IA, Cornillie, FJ and Fasquez, G (1986). Etiology and pathophysiology of endometriosis. In: Rolland, R, Chadha Dev, R, Willemsen, WNP (eds.) “Gonadotrophin Down-Regulation in Gynecological Practice”. Vol 81, p.102. (New York: Alan R. Liss) Janne, O, Kauppila, A, Kokko, E, Lanto, T, Ronnberg, L and Vikko, R (1981). Estrogen and progestin receptors in endometriosis lesions: Comparison with endometrial tissue. Am J Obstet Gynecol, 141, 562 Buttram, VC Jr (1985). Treatment of endometriosis with danazol: report of a 6-year prospective study. Fertil Steril, 43, 353 Brosens, IA, Verleyen, A and Cornillie, F (1987). The morphologic effect of short-term medical therapy of endometriosis. Am J Obstet Gynecol, 157, 1215 Schweppe, KW, Dmowski, WP and Wynn, RM (1981). Ultrastructural changes in endometriotic tissue during danazal treatment. Fertil Steril, 36, 20 Author information Authors and Affiliations Editor information Rights and permissions Copyright information © 1990 Kluwer Academic Publishers About this chapter Cite this chapter Brosens, I.A., Cornillie, F., Puttemans, P. (1990). Is There a Rationale for GnRH Analogue Therapy in Endometriosis?. In: Vickery, B.H., Lunenfeld, B. (eds) GnRH Analogues in Reproduction and Gynecology. Springer, Dordrecht. https://doi.org/10.1007/978-94-009-0721-8_1 Download citation DOI: https://doi.org/10.1007/978-94-009-0721-8_1 Publisher Name: Springer, Dordrecht Print ISBN: 978-94-010-6809-3 Online ISBN: 978-94-009-0721-8 eBook Packages: Springer Book Archive

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endometriosis

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