The morphologic effect of short-term medical therapy of endometriosis

Ivo Brosens, I A Brosens, Brosens IA, Ann Verleyen, A Verleyen, Verleyen A, F Cornillie, Cornillie F, Freddy Cornillie
American journal of obstetrics and gynecology · 1987 · vol. 157(5) , pp. 1215–1221 · doi:10.1016/s0002-9378(87)80297-1 · PMID:3688077 · W2010345295
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This study investigated the morphological changes in endometriosis lesions following short-term medical treatment.

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Abstract

A clinicopathologic study of a short-term medical treatment of endometriosis with danazol or gestrinone was performed in 50 patients with endometriosis and infertility. The cellular response to the therapy was evaluated and graded according to morphologic, that is, histologic and ultrastructural, criteria. A 2-month therapy with 1.25 mg of gestrinone daily induced a degree of cellular inactivation and degeneration of the endometriotic implants that was more pronounced than after 4 months of therapy with either gestrinone (2.5 mg twice or thrice weekly) or danazol (600 mg daily). There was no correlation between the morphologic response to treatment and either the hormonal response of the foci during the menstrual cycle before therapy or the change in laparoscopic staging of endometriosis at the end of therapy. It is suggested that a short-term medical treatment should be further evaluated clinically in the treatment of endometriosis and infertility.

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Condition tags

endometriosis

MeSH descriptors

Danazol Endometriosis Gestrinone Norpregnatrienes Ovarian Neoplasms Peritoneal Neoplasms Pregnadienes Biopsy Danazol Endometriosis Endometriosis Female Gestrinone Humans Infertility, Female Infertility, Female Menstrual Cycle Norpregnatrienes Ovarian Neoplasms Ovarian Neoplasms

Citation neighborhood

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

References (11)

Cited by (42)

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