Medical Management of Endometriosis

Luigi Fedele, Stefano Bianchi, Eleonora Fontana, Nicola Berlanda, Giada Frontino, Alessandro Bulfoni
Women's health (London, England) · 2006 · vol. 2(2) , pp. 297–308 · doi:10.2217/17455057.2.2.297 · PMID:19803901 · W2140109298
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⚙ AI-generated summary by claude@2026-06, 2026-06-10 ⓘ

Current endometriosis treatments suppress ovarian steroids to induce atrophy of ectopic endometrium, but new therapies targeting molecular mechanisms are being developed to improve safety and efficacy.

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Abstract

Current approved medical therapies for endometriosis rely on drugs that suppress ovarian steroids and induce a hypoestrogenic state, which determines the atrophy of the ectopic endometrium. Gonadotropin-releasing hormone analogs such as danazol, progestogens and estrogen-progestin combinations have all proven effective in relieving pain and reducing the extent of endometriotic implants. However, symptoms often recur after discontinuation of therapy and hypoestrogenism-related side effects limit the long-term use of most medications. Recently, knowledge of the pathogenesis of endometriosis, particularly at the molecular level, has grown substantially, providing a rational basis for the development of new drugs with precise targets that may be safely administered over the long term.

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endometriosis

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Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

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