Historical prospective cohort study of the recurrence of pain after discontinuation of treatment with danazol or a gonadotropin- releasing hormone agonist

James D. Miller, J D Miller, Miller JD, Robert W. Shaw, R W Shaw, Shaw RW, R F Casper, Casper RF, Robert F. Casper, John A. Rock, J A Rock, Thomas EJ, Eric J. Thomas, E J Thomas, W P Dmowski, Dmowski WP, W. Paul Dmowski, E Surrey, Eric S. Surrey, Surrey E, Malinak LR, L.Russel Malinak, L R Malinak, Moghissi K, K Moghissi, Kamran S. Moghissi
Fertility and Sterility · 1998 · vol. 70(2) , pp. 293–296 · doi:10.1016/s0015-0282(98)00166-6 · PMID:9696224 · W2047533080
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This historical prospective cohort study investigated the recurrence rates of pain following discontinuation of danazol versus gonadotropin-releasing hormone agonist treatment.

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Abstract

ObjectiveTo determine the duration of time to the recurrence of pain attributable to endometriosis after the discontinuation of treatment with danazol or a GnRH agonist (GnRH-a) in patients who have had a satisfactory response to the treatment.DesignRetrospective study.SettingNine academic medical centers in three countries.Patient(s)Three hundred twenty-seven women with diagnosed and staged endometriosis who were treated with at least 6 months of danazol or a GnRH-a and who experienced significant pain relief with therapy.Intervention(s)None.Main outcome measure(s)Duration of pain relief after completion of treatment as determined by a patient-initiated report of pain recurrence or increase in pain severity requiring intervention.Result(s)The median time to the recurrence of pain was 6.1 months for patients treated with danazol and 5.2 months for patients treated with a GnRH-a.Conclusion(s)Although there was a lack of uniformity in treatment effects across sites, the analyses have taken into account major covariant effects. The time to the recurrence of endometriosis-associated pain after danazol treatment was slightly longer than that after GnRH-a treatment.

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Condition tags

endometriosis

MeSH descriptors

Danazol Endometriosis Estrogen Antagonists Pain Receptors, LHRH Adult Danazol Endometriosis Endometriosis Estrogen Antagonists Female Humans Multicenter Studies as Topic Pain Receptors, LHRH Recurrence Retrospective Studies

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Cited by (37)

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