Treatment with leuprolide acetate and hormonal add-back for up to 10 years in stage IV endometriosis patients with chronic pelvic pain

Mohamed A. Bedaiwy, Casper RF, Robert F. Casper
Fertility and sterility · 2006 · vol. 86(1) , pp. 220–222 · doi:10.1016/j.fertnstert.2005.12.030 · PMID:16716325 · W2088497898
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⚙ AI-generated summary by claude@2026-06, 2026-06-06 ⓘ

This study investigated the long-term efficacy and safety of leuprolide acetate with hormonal add-back therapy for managing chronic pelvic pain in patients with stage IV endometriosis over a 10-year period.

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Abstract

This pilot study examined the effect of a low-dose E and pulsed progestogen hormone therapy (HT) regimen for add-back during long-term GnRH-agonist therapy on bone mineral density (BMD) in five patients with stage IV endometriosis. Bone mineral density was stable after initiation of HT for the entire follow-up period (up to 10 years). One patient stopped her treatment on two occasions to conceive and was successful each time with delivery of a normal baby. No patient had return of pelvic pain after HT add-back.

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Condition tags

endometriosischronic_pelvic_pain

MeSH descriptors

Bone Demineralization, Pathologic Bone Demineralization, Pathologic Endometriosis Estradiol Leuprolide Pelvic Pain Progestins Adult Bone Demineralization, Pathologic Bone Density Bone Density Chronic Disease Drug Combinations Endometriosis Endometriosis Estradiol Female Fertility Agents, Female Fertility Agents, Female Hormone Replacement Therapy

Citation neighborhood

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

References (15)

Cited by (50)

Source provenance

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