Optimal management of chronic cyclical pelvic pain: an evidence-based and pragmatic approach
This review discusses the identification and management of chronic cyclical pelvic pain in women, from initial assessment to treatment options like oral contraceptives, given a lack of high-quality evidence.
One-sentence paraphrase of the abstract; not a substitute for reading it. No clinical advice. How this works
This paper is an evidence-based, pragmatic review of the literature on managing chronic cyclical pelvic pain, using searches of multiple databases (Medline, PubMed, CINAHL, Cochrane Library, Current Contents, and EMBASE) with MeSH terms and keywords including endometriosis and dysmenorrhea. It reports that high-quality evidence is scarce for this common problem (estimated to affect 4%–25% of reproductive-age women), and it summarizes that endometriosis is identified as the most common pathological cause, with other gynecologic contributors including adenomyosis, uterine fibroids, and pelvic floor myalgia. The review describes an approach to evaluation and management based on history, physical examination, and investigations to identify pain causes, while noting that management options span from simple medical treatments (e.g., combined oral contraceptive pill as a first-line option) to invasive strategies. This paper is centrally about endometriosis — it explicitly frames endometriosis as the commonest pathological cause of chronic cyclical pelvic pain and discusses it within an evidence-based management approach, with adenomyosis also listed among other gynecologic causes.
Read from the paper's body, not the abstract. Not a substitute for reading the paper. No clinical advice. How this works
Abstract
Full text
2,288 characters
· extracted from
oa-doi-fallback
· 2 sections
· click to expand
Abstract
Keywords
Text is read by the "Ask this paper" AI Q&A widget below. Extraction quality varies by source — PMC NXML preserves structure cleanly, OA-HTML may include some navigation residue, and OA-PDF can have broken hyphenation. The publisher copy (via DOI) is the canonical version.
My notes (saved in your browser only)
Answers must be backed by verbatim quotes from this paper's full text. Hallucinated quotes are dropped automatically; if no verbatim passage answers the question, we say so. How this works
Condition tags
Citation neighborhood
Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.
References (100)
- Adenomyosis of the uterus. via openalex
- A gonadotropin-releasing hormone agonist versus a low-dose oral contraceptive for pelvic pain associated with endometriosis via openalex
- A prospective, randomized, double‐blind controlled trial of laparoscopic uterine nerve ablation in the treatment of pelvic pain associated with endometriosis via openalex
- A randomized trial of excision versus ablation for mild endometriosis via openalex
- Chronic Pelvic Pain: How Many Surgeries Are Enough? via openalex
- Chronic pelvic pain in New Zealand: prevalence, pain severity, diagnoses and use of the health services via openalex
- Chronic pelvic pain in the community—Symptoms, investigations, and diagnoses via openalex
- Chronic Pelvic Pain: Prevalence, Health-Related Quality of Life, and Economic Correlates via openalex
- Clinical features of women with chronic lower abdominal pain and pelvic congestion via openalex
- Comparison of CO2 laser laparoscopy with laparotomy for treatment of endometriomata via openalex
- Correlation between endometriosis and pelvic pain via openalex
- Cyclic Pelvic Pain via openalex
- Depot medroxyprogesterone acetate versus an oral contraceptive combined with very-low-dose danazol for long-term treatment of pelvic pain associated with endometriosis via openalex
- Different types of small nerve fibers in eutopic endometrium and myometrium in women with endometriosis via openalex
- Do gastrointestinal symptoms vary with the menstrual cycle? via openalex
- Effectiveness of inpatient and outpatient treatment strategies for women with pelvic inflammatory disease: Results from the pelvic inflammatory disease evaluation and clinical health (peach) randomized trial via openalex
- Effect of leuprolide acetate in patients with moderate to severe functional bowel disease via openalex
- Efficacy of vaginal danazol treatment in women with recurrent deeply infiltrating endometriosis via openalex
- Endocrine Regulation of Menstruation via openalex
- Endometriosis and Endosalpingiosis via openalex
- Endometriosis and Endosalpingiosis via openalex
- Endosalpingiosis: Clinical Presentation and Follow-Up via openalex
- Etiology and epidemiology of endometriosis via openalex
- Functional ovarian cysts in premenopausal and gynecologically healthy women via openalex
- Gonadotropin-releasing hormone analogue plus hormone replacement therapy for the treatment of endometriosis: a randomized controlled trial. via openalex
- Hormonal manipulation in women with chronic, cyclic irritable bladder symptoms and pelvic pain via openalex
- Irritable bowel syndrome in women having diagnostic laparoscopy or hysterectomy via openalex
- Laparoscopic excision of endometriosis: A randomized, placebo-controlled trial via openalex
- Laparoscopy and Reported Pain among Patients with Endometriosis via openalex
- Laser laparoscopy. A new modality. via openalex
- Laser laparoscopy: A new modality via openalex
- Low-dose oral contraceptive pill for dysmenorrhea associated with endometriosis: a placebo-controlled, double-blind, randomized trial via openalex
- Lower quality of life among women with chronic pelvic pain after pelvic inflammatory disease*1 via openalex
- Magnetic resonance imaging and transvaginal ultrasonography for the diagnosis of adenomyosis via openalex
- Menstrual symptoms in women with pelvic endometriosis via openalex
- Menstrual Symptoms in Women With Pelvic Endometriosis via openalex
- Pain symptoms associated with endometriosis. via openalex
- Placebo-controlled comparison of danazol and high-dose medroxyprogesterone acetate in the treatment of endometriosis via openalex
- Post-ablation-tubal sterilization syndrome. via openalex
- Posture, movement patterns, and body awareness in women with chronic pelvic pain via openalex
- Prevalence and Characteristics of Irritable Bowel Syndrome Among Women With Chronic Pelvic Pain via openalex
- Prevalence and incidence of chronic pelvic pain in primary care: evidence from a national general practice database via openalex
- Prevalence of Endometriosis in Adolescent Girls With Chronic Pelvic Pain Not Responding to Conventional Therapy via openalex
- Progestins for symptomatic endometriosis: a critical analysis of the evidence via openalex
- Prospective, randomized, double-blind, controlled trial of laser laparoscopy in the treatment of pelvic pain associated with minimal, mild, and moderate endometriosis via openalex
- Prospective, randomized, double‐blind, controlled trial of laser laparoscopy in the treatment of pelvic pain associated with minimal, mild, and moderate endometriosis via openalex
- Prostaglandins in primary dysmenorrhea via openalex
- Randomized controlled trial of depot leuprolide in patients with chronic pelvic pain and clinically suspected endometriosis via openalex
- Randomized Controlled Trial of Depot Leuprolide in Patients With Chronic Pelvic Pain and Clinically Suspected Endometriosis via openalex
- Rectosigmoid endometriosis. Diagnosis using endovaginal sonography. via openalex
- Rectosigmoid Endometriosis: Endoscopic Ultrasound Features and Clinical Implications via openalex
- Screening for Musculoskeletal Causes of Pelvic Pain via openalex
- Surgical and medical treatment of adenomyosis via openalex
- The diagnosis and management of infiltrating nodular recto-vaginal endometriosis via openalex
- The effects and effectiveness of laparoscopic excision of endometriosis: a prospective study with 2-5 year follow-up via openalex
- The Efficacy and Complications of Laparoscopic Presacral Neurectomy in Pelvic Pain via openalex
- The LNG-IUS study on adenomyosis: a 3-year follow-up study on the efficacy and side effects of the use of levonorgestrel intrauterine system for the treatment of dysmenorrhea associated with adenomyosis via openalex
- The Use of Botulinum Toxin in the Pelvic Floor for Women with Chronic Pelvic Pain–A New Answer to Old Problems? via openalex
- Treatment with leuprolide acetate and hormonal add-back for up to 10 years in stage IV endometriosis patients with chronic pelvic pain via openalex
- Ultrasonography compared with magnetic resonance imaging for the diagnosis of adenomyosis: correlation with histopathology via openalex
- Uterine myomas, dyspareunia, and sexual function via openalex
- Valdecoxib, a cyclooxygenase-2-specific inhibitor, is effective in treating primary dysmenorrhea via openalex
- Valdecoxib, a Cyclooxygenase-2-Specific Inhibitor, Is Effective in Treating Primary Dysmenorrhea via openalex
- Zoladex (goserelin acetate implant) in the treatment of endometriosis: a randomized comparison with danazol. The Zoladex Endometriosis Study Group. via openalex
- W2419514674 via openalex
- W2435415209 via openalex
- W2474401381 via openalex
- W3012576582 via openalex
- W3023257017 via openalex
- W4230580944 via openalex
- W4232346455 via openalex
- W6601001701 via openalex
- W6601564371 via openalex
- W6640714295 via openalex
- W6643093297 via openalex
- W6648186389 via openalex
- W6662144757 via openalex
- W6673633195 via openalex
- W6676283717 via openalex
- W6715807690 via openalex
- W19692800 via openalex
- W6720750044 via openalex
- W38273247 via openalex
- W108337335 via openalex
- W148312605 via openalex
- W246493134 via openalex
- W1486352899 via openalex
- W1501381413 via openalex
- W1601514157 via openalex
- W1606920119 via openalex
- W1661158834 via openalex
- W1768851900 via openalex
- W1946443235 via openalex
- W1969018878 via openalex
- W1971862189 via openalex
- W1975584002 via openalex
- W1976044138 via openalex
- W1977416672 via openalex
- W1980970464 via openalex
- W1982841532 via openalex
Cited by (17)
- Head to toe: expand your diagnosis on routine imaging to include endometriosis 2025
- Pain Severity and Depressive Symptoms in Endometriosis Patients: Mediation of Negative Body Awareness and Interoceptive Self-Regulation 2024
- The role of catastrophizing in chronic cyclical pelvic pain: A systematic review and meta-analysis 2023
- Development of a core outcome set and outcome definitions for studies on uterus-sparing treatments of adenomyosis (COSAR): an international multistakeholder-modified Delphi consensus study 2022
- Prevalence of chronic pelvic pain and primary dysmenorrhea in women of reproductive age in Ecuador 2022
- Endometriosis: A Common and Commonly Missed and Delayed Diagnosis 2021
- The Importance of a Multi-Disciplinary Approach to the Endometriotic Patients: The Relationship between Endometriosis and Psychic Vulnerability 2021
- Is Idiopathic Chronic Pelvic Pain a Treatable Entity: A Comment 2016
- Hyperalgesiemechanismen bei Patientinnen mit Endometriose 2015
- Chronic pelvic pain in Spanish women: prevalence and associated risk factors. A cross-sectional study 2014
- Abdominopelvic pain syndromes 2014
- Improvement in chronic pelvic pain after gonadotropin releasing hormone analogue (GnRH-a) administration in premenopausal women suffering from adenomyosis or endometriosis: a retrospective study 2013
- Diagnostic laparoscopy in chronic pelvic pain: What are the issues in a resource poor country? 2012
- Chronic pelvic pain: gynaecological and non‐gynaecological causes and considerations for nursing care 2012
- Intraoperative Detection of Subtle Endometriosis: A Novel Paradigm for Detection and Treatment of Pelvic Pain Associated with the Loss of Peritoneal Integrity 2012
- PAPEL DE LA CISTOSCOPIA EN EL ESTUDIO DE LAS PACIENTES CON DOLOR PéLVICO CRÓNICO: ESTUDIO OBSERVACIONAL The role of cystoscopy when studying patients suffering from chronic pelvic pain: an observational study 2011
- Medical and surgical management of chronic pelvic pain 2011
Source provenance
- europepmc
- last seen: 2026-06-04T01:30:01.192114+00:00
- openalex
- last seen: 2026-06-04T00:00:01.174412+00:00
- pubmed
- last seen: 2026-05-13T22:16:54.825375+00:00