Improvement in chronic pelvic pain after gonadotropin releasing hormone analogue (GnRH-a) administration in premenopausal women suffering from adenomyosis or endometriosis: a retrospective study

Morelli M, Michele Morelli, Morena Luigia Rocca, M. Rocca, Roberta Venturella, Mocciaro R, Rita Mocciaro, Zullo F, Fulvio Zullo
Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology · 2013 · vol. 29(4) , pp. 305–308 · doi:10.3109/09513590.2012.743017 · PMID:23323768 · W2061815677
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Gonadotropin releasing hormone analogue administration significantly reduced chronic pelvic pain, analgesic use, and lost work productivity in premenopausal women with adenomyosis or endometriosis, with a greater effect observed in those with adenomyosis.

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Abstract

The aim of this study was to evaluate the improvement in catamenial chronic pelvic pain (CPP) after Gonadotropin Releasing Hormone analogue (GnRH-a) administration in women affected by adenomyosis or endometriosis. We retrospectively analysed clinical data of 63 premenopausal women with clinical suspect of adenomyosis (15 women, Group A) or endometriosis (48 women, Group B), which received GnRH-a in order to reduce CPP intensity during the time on surgery waiting list. Main outcome measures were variation of CPP intensity, numbers of days requiring analgesics and lost work productivity before and three months after GnRH-a administration. Compared to baseline, a significant decrease in CPP intensity (p < 0.05) was observed in both groups, even if this reduction was significantly higher in Group A than in Group B (p < 0.001). In both groups, moreover, a significant reduction in number of days requiring analgesics (p < 0.05) and lost work productivity (p < 0.05) was detected. In conclusion, GnRH-a administration in women with clinical suspect of adenomyosis induces a greater reduction in CPP when compared to women with endometriosis, thus representing a potential ex adiuvantibus criteria, helping TV-US in the clinical diagnosis of adenomyosis.

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Condition tags

endometriosischronic_pelvic_painadenomyosis

MeSH descriptors

Adenomyosis Chronic Pain Endometriosis Leuprolide Ovarian Diseases Pelvic Pain Adenomyosis Adenomyosis Adult Chronic Pain Chronic Pain Endometriosis Endometriosis Female Humans Leuprolide Middle Aged Ovarian Diseases Ovarian Diseases Pelvic Pain

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References (19)

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