Depot leuprolide versus danazol in treatment of women with symptomatic endometriosis
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This study compared depot leuprolide to danazol for treating women with symptomatic endometriosis.
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Abstract
ObjectiveWe aimed to assess the efficacy of depot leuprolide versus danazol in the treatment of endometriosis.Study designA double-blind randomized trial of 270 patients from 22 centers compared the pretreatment and posttreatment laparoscopic extent of endometriosis. Pretreatment and posttreatment endometriosis symptoms and signs were assessed with standardized methods.ResultsWhen compared with danazol, leuprolide depot caused a more rapid and profound suppression of estradiol. Leuprolide depot and danazol were similarly efficacious in decreasing the extent of endometriosis, as well as the pain and tenderness associated with endometriosis.ConclusionDepot leuprolide is an effective alternative to danazol in decreasing the extent of endometriosis and endometriosis-related pain.
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- Hormonal Therapy in Endometriosis and Adenomyosis: Danazol, Aromatase Inhibitors 2022
- Medical therapy options for endometriosis related pain, which is better? A systematic review and network meta-analysis of randomized controlled trials 2020
- Patient preferences for elagolix and leuprolide for treating endometriosis-related pain in the United States 2020
- Diagnosis and treatment of endometriosis 2019
- Development and Validation of the Endometriosis Daily Pain Impact Diary Items to Assess Dysmenorrhea and Nonmenstrual Pelvic Pain 2018
- Current and Emerging Therapeutics for the Management of Endometriosis 2018
- Reevaluating response and failure of medical treatment of endometriosis: a systematic review 2017
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- Theranekron for treatment of endometriosis in a rat model compared with medroxyprogesterone acetate and leuprolide acetate 2013
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- Long-term effects on bone mineral density and bone metabolism of 6 months’ treatment with gonadotropin-releasing hormone analogues in Japanese women: comparison of buserelin acetate with leuprolide acetate 2005
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- Tumor Necrosis Factor-α-Induced Interleukin-8 (IL-8) Expression in Endometriotic Stromal Cells, Probably through Nuclear Factor-κB Activation: Gonadotropin-Releasing Hormone Agonist Treatment Reduced IL-8 Expression 2003
- Prolonged GnRH agonist and add-back therapy for symptomatic endometriosis: long-term follow-up*1 2002
- The Treatment of Endometriosis 2002
- The efficacy of medical and surgical treatment of endometriosis-associated infertility: arguments in favour of a medico-surgical aproach 2002
- Consensus statement for the management of chronic pelvic pain and endometriosis: proceedings of an expert-panel consensus process 2002
- Prolonged GnRH Agonist and Add-Back Therapy for Symptomatic Endometriosis 2002
- Dienogest is as effective as triptorelin in the treatment of endometriosis after laparoscopic surgery: results of a prospective, multicenter, randomized study 2002
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