Efficacy of levamisole on experimental endometriosis

Gönül Öçal, G Ocal, A Kokcu, A. Kökçü, Mehmet Çetinkaya, M B Cetinkaya, M Tosun, Mehmet Kefeli, M Kefeli, B Kandemir, Bedrı Kandemır
International Journal of Gynecology & Obstetrics · 2007 · vol. 99(1) , pp. 38–42 · doi:10.1016/j.ijgo.2007.04.041 · PMID:17678930 · W2062216951
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Levamisole was found to be as effective as leuprolide in decreasing the volume of experimental endometriosis implants in rats.

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Abstract

OBJECTIVE: To investigate the efficacy of levamisole on experimental endometriosis. METHODS: After the implantation of endometrial tissue on abdominal peritoneum, 40 rats were randomized to 1 of 4 equal intervention groups. Levamisole (2 mg/rat) was applied subcutaneously to group "L" once a week. Depot medroxyprogesterone acetate (3 mg/kg) was applied intramuscularly to group "M" twice at 4-week intervals. Leuprolide (0.075 mg/kg) was applied subcutaneously to group "G" twice at 4-week intervals. Saline (0.1 cm(3)/rat) was applied subcutaneously to group "C" once a week for 8 weeks. The efficacy of levamisole was determined by volume measurement and characterizing the histological structure of the implants. RESULT: Volume increase of the implants in group C (P<0.05), and volume decrease in groups M, G, and L was found (P<0.05, P<0.01, and P<0.01, respectively.) Stromal tissue and glandular activity were not different between groups L and G. CONCLUSION: Levamisole was found to be as effective as leuprolide in regression of the volume of endometriotic implants.

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Condition tags

mesh:D004715endometriosis

MeSH descriptors

Adjuvants, Immunologic Endometriosis Levamisole Adjuvants, Immunologic Animals Contraceptive Agents, Female Contraceptive Agents, Female Delayed-Action Preparations Disease Models, Animal Endometriosis Endometriosis Female Fertility Agents, Female Fertility Agents, Female Gonadotropin-Releasing Hormone Injections, Intramuscular Injections, Subcutaneous Leuprolide Leuprolide Levamisole

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References (30)

Cited by (11)

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