Therapeutic Efficiency of Tibolone in a Rat Endometriosis Model

Yavuz Şimşek, Temel Ceyhan, Yusuf Üstün, Tayfun İDE, Şevki Çelen, Erdoğan Akar, Yusuf Sirin, Semih Kaleli
In: Turkiye Klinikleri Journal of Medical Sciences · 2011 · vol. 31(6) , pp. 1351–1355 · doi:10.5336/medsci.2010-19821 · W2090747089
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⚙ AI-generated summary by claude@2026-06, 2026-06-06 ⓘ

Tibolone demonstrated therapeutic efficiency in a rat endometriosis model, significantly reducing endometriotic foci dimensions, comparable to leuprolide acetate treatment.

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⚙ AI-generated deep summary by claude@2026-06, 2026-06-06 ⓘ

This experimental study induced intrabdominal endometriosis in 30 female rats and, after a second laparotomy 28 days later, randomized the remaining animals into three treatment groups receiving either saline (control), intramuscular leuprolide acetate, or oral tibolone (1 mg/kg/day) for 4 weeks. After treatment, all rats underwent a laparotomy again and the dimensions/area of endometriotic foci and the intra-abdominal adhesion scores were measured and compared among groups. The endometriotic focus dimensions were significantly reduced versus control in both the leuprolide and tibolone groups (p<0.05), while no statistically significant differences were found between the two treatment groups. The study relates directly to endometriosis—tibolone’s therapeutic efficiency was evaluated in a rat endometriosis model and compared with the conventional GnRHa leuprolide.

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Abstract

Objective: This study aimed to evaluate the therapeutic efficiency of tibolone in an experimental rat model of intra-abdominal endometriosis. Material and Methods: In this experimental study, intra-abdominal endometriosis was induced in 30 female rats surgically. Four weeks after this procedure, laparotomy was performed again. The dimensions of the endometriosis foci were recorded and right after, the operation was completed. Rats were randomly divided into three groups and subsequently, the treatment was started. In the first group (n= 8), a single dose of 1 cc 0.9% NaCl was injected subcutaneously. In the second group (n= 8), intramuscular injection of 1 mg leuprolid acetate was administered. In the third group (n= 8), 1 mg/kg/day of tibolone was given by gavage. At the end of 4- weeks of drug administration, laparotomy was performed to all rats. The dimensions of the endometriosis foci were recorded. Afterwards, all the rats were sacrificed. The differences in the areas of endometriotic implants and adhesion scores were compared between the groups. Results: The dimensions of the endometriosis foci in the groups treated with leuprolid (p< 0.05) and tibolone (p< 0.05) were significantly diminished compared to that of the control group. No statistically significant differences were found between the treatment groups. Conclusion: In a rat endometriosis model, tibolone has a similar efficiency as that of leuprolid acetate, an agent used for conventional medical treatment of endometriosis. With its androgenic and progestagenic characteristics, tibolone deserves attention as an alternative agent in the medical treatment of endometriosis in human.

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endometriosis

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