Comparison of the effects of cetrorelix, a GnRH antagonist, and leuprolide, a GnRH agonist, on experimental endometriosis

Devrim Altintas, Arif Kökçü, Arif Kokcu, Migraci Tosun, Miğraci Tosun, Mehmet B Cetinkaya, Mehmet Çetinkaya, Bedrı Kandemır, Bedri Kandemir
Journal of Obstetrics and Gynaecology Research · 2008 · vol. 34(6) , pp. 1014–1019 · doi:10.1111/j.1447-0756.2008.00807.x · PMID:19012701 · W2019310620
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This study found that cetrorelix and leuprolide equally reduced the volume and histological features of experimental endometriosis implants in rats compared to a control group.

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Abstract

AIM: In the present study, we aimed to compare the effects of cetrorelix and leuprolide on endometriosis. METHODS: This randomized, placebo-controlled, single-blind, experimental study was performed on 45 Wistar adult female rats in the Experimental Surgery Laboratory at Ondokuz Mayis University. After the peritoneal implantation of endometrial tissue, rats were randomized to three equal intervention groups: (i) control group, (ii) leuprolide group, and (iii) cetrorelix group. Six weeks later, following implant volume measurements (volume-1) by performing a second laparotomy, saline (0.1 cc/rat) was administered subcutaneously to the control group once a week, leuprolide (0.075 mg/kg) subcutaneously to the leuprolide group twice at 4-week intervals and cetrorelix (0.001 mg/rat/day) subcutaneously to the cetrorelix group for 8 weeks. At the end of the treatment, by performing a third laparotomy, implant volumes were remeasured (volume-2) and implants were totally excised for histopathological examination. The volume-1 and volume-2 values within the groups, and stromal and glandular tissue scores between the groups were compared. RESULTS: In both the leuprolide group and the cetrorelix group, volume-2 as compared to volume-1 had significantly reduced (P < 0.01, P 0.05). In this group, when compared with the control group, glandular and stromal tissues had significantly lessened (P < 0.01, P < 0.01 respectively). CONCLUSION: Leuprolide and cetrorelix were found to have similar efficacy in the regression of both the size and the histological structure of experimental endometriotic implants.

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Condition tags

endometriosis

MeSH descriptors

Antineoplastic Agents, Hormonal Endometriosis Gonadotropin-Releasing Hormone Hormone Antagonists Leuprolide Animals Antineoplastic Agents, Hormonal Endometriosis Endometriosis Female Gonadotropin-Releasing Hormone Gonadotropin-Releasing Hormone Gonadotropin-Releasing Hormone Hormone Antagonists Laparotomy Leuprolide Random Allocation Rats Rats, Wistar Single-Blind Method

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Cited by (32)

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