Dinitrosyl iron complexes with cysteine suppress the development of experimental endometriosis in rats

E. N. Burgova, L.V. Adamyan, N. A. Tkachev, A. A. Stepanyan, А. Ф. Ванин
In: Biophysics · 2012 · vol. 57(1) , pp. 87–89 · doi:10.1134/s0006350912010071 · W2025376465
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Daily injections of dinitrosyl iron complexes with cysteine reduced the size of experimental endometriomas in rats by 1.85 times.

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This paper studied whether dinitrosyl iron complexes (DNIC) administered with cysteine could suppress surgically induced experimental endometriosis in rats. In the reported experimental protocol, daily injection for 10 days of 0.5 mL aqueous DNIC at 5 mM reduced the mean size of endometriomas to 1.85-fold smaller than in controls. The authors propose that nitric oxide molecules and nitrosonium ions released from DNIC rapidly decompose in the organism and exert cytotoxic effects on endometrioid tissue. This paper is centrally about endometriosis — it tests DNIC with cysteine for suppressing development of experimental endometriosis in rats.

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Abstract

Administration of dinitrosyl iron complexes (DNIC) with cysteine suppressed the development of experimental (surgically induced) endometriosis in rats: the mean size of endometrioma was 1.85 times smaller if 0.5 mL of a 5 mM aqueous solution of DNIC had been injected daily for 10 days. It is supposed that NO molecules and nitrosonium ions (NO+), released from DNIC rapidly decomposed in the organism, prove cytotoxic for endometrioid tissue.
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Abstract

Administration of dinitrosyl iron complexes (DNIC) with cysteine suppressed the development of experimental (surgically induced) endometriosis in rats: the mean size of endometrioma was 1.85 times smaller if 0.5 mL of a 5 mM aqueous solution of DNIC had been injected daily for 10 days. It is supposed that NO molecules and nitrosonium ions (NO+), released from DNIC rapidly decomposed in the organism, prove cytotoxic for endometrioid tissue. Similar content being viewed by others

References

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