L.V. Adamyan

Determining the pathogenesis of endometriosis remains a major challenge in contemporary gynecology, and the investigation of alterations in cellular immunity may provide important insights into this issue. A comprehensive search of electron…

Benign uterine diseases remain among the leading causes of surgical interventions in women of reproductive age. A forty-year cumulative clinical experience (1986—2026) demonstrates that the effectiveness of reconstructive and uterus-preserv…

Background. One of the key challenges in modern gynecology remains the diagnostic delay in endometriosis, which averages 7 to 12 years from the onset of first symptoms to the establishment of the diagnosis. This delay is primarily due to th…

External genital endometriosis (EGE) and premature ovarian failure (POF) are among the most common and socially significant gynecological diseases, impairing patients' quality of life and forcing women to resort to assisted reproductive tec…

This Resolution was prepared following the Expert Council meeting entitled «Endometriosis as a Fibro-Inflammatory Disease: The Role of Enzyme Therapy in the Comprehensive Management of Endometriosis-Associated Conditions,» held on June 3, 2…

The endometrium during menstruation, as well as its fragments during intraperitoneal regurgitation, exhibit signs of aseptic inflammation. Therefore, the review summarizes current data on the possible mechanisms of survival and growth of en…

Genital endometriosis is a chronic multisystem disease in which pain syndrome remains the leading clinical manifestation. Despite significant advances in understanding the pathogenesis of endometriosis, the mechanisms of pain generation and…

The incidence of ovarian endometrioma (OMA) among patients undergoing assisted reproductive technology (ART) programs ranges from 10.5 to 21.8%. Despite data on the possible gonadotoxic effect of OMA, their impact on the outcomes of ART pro…

Endometriosis is a gynecological disease affecting more than 190 million women of reproductive age worldwide, characterized by a complex molecular pathophysiology encompassing genetic, epigenetic, inflammatory, and immunological components.…

I ntroduction. The innate immune system plays a leading role in the initiation and progression of external genital endometriosis (EGE) lesions. Aim. Тo analyze the content of subpopulations of immunocompetent cells and the level of cytokine…

Chronic pelvic pain is the most common symptom of endometriosis. Objective. To evaluate the effectiveness of amitriptyline for chronic pelvic pain associated with endometriosis. Material and methods. A comparative analysis of the results of…

Endometriosis is a gynecological disorder characterized by the presence of tissue that is morphologically and functionally similar to the endometrium, but located outside the uterine cavity. The disease is chronic and prone to recurrence. A…

This systematic review aimed to summarize all available data and evaluate the roles of E-cadherin, N-cadherin, associated molecules, and signaling pathways in the pathogenesis of endometriosis. The search was conducted on PubMed, Cochrane L…

• The limitations of EBM and guidelines to take dichotomous decisions, based on multiple variables, are discussed for endometriosis management. • It is suggested to document for clinical decisions on diagnosis, treatment and surgery the col…

The article focuses on the of methods for objectifying pain syndrome in patients with endometriosis. Endometriosis-related pain, including dysmenorrhea, dyspareunia, and chronic pelvic pain, is a clinically significant symptom of the diseas…

Background/Objectives: The diagnosis and treatment of endometriosis should be based on the best available evidence. Emphasising the risk of bias, the pyramid of evidence has the double-blind, randomised controlled trial and its meta-analyse…

The aim of this review is to analyse contemporary scientific evidence concerning the role and significance of macrophage polarisation in the pathogenesis of endometriosis. Particular emphasis is placed on the molecular and cellular mechanis…

Objective. Optimization of diagnostic methods for studying the myometrium in adenomyosis using magnetic resonance imaging (MRI) and subsequent construction of a three-dimensional model of the uterus using computer-assisted technologies to o…

Objective. Analysis of immunohistochemical expression of β1- and β2-adrenergic receptors (ADRB1 and ADRB2) in adenomyotic tissues in reproductive-age patients. Material and methods. The study included histological preparations and paraffin …