Visceral Pain Models, Female Reproductive Organ Pain

Synonyms Female Reproductive Organ Pain Model; Gynecological Pain Model; Endometriosis Model; Labor Pain Model; Dyspareunia Model; Vaginal Hyperalgesia Model; Chronic Pelvic Pain Model Definition A “model” of pain refers to a non-human animal treated in a manner that mimics a painful human condition or disease. The model can then be used both to improve knowledge of mechanisms that might underlie the condition/disease and its relation to pain and to develop better treatments. Models of visceral pain usually refer to animals that currently have or have had some type of pathophysiology of an internal organ. For female reproductive organs, the models would have been treated in ways that can mimic pain associated with female reproductive organs; i.e. gynecological pain. Of utmost importance in interpreting results from studies using animal models is recognition of limitations inherent in translating results to humans. Characteristics In general, there are five main procedural steps for... Access this chapter Tax calculation will be finalised at checkout Purchases are for personal use only References Berkley KJ, Wood E, Scofield SL, Little M (1995) Behavioral Responses to Uterine or Vaginal Distension in the Rat. Pain 61:121–131 Bradshaw HB, Berkley KJ (2002) Estrogen Replacement Reverses Ovariectomy-Induced Vaginal Hyperalgesia in the Rat. Maturitas 41:157–165 Bradshaw HB, Berkley KJ (2003) The Influence of Ovariectomy with or without Estrogen Replacement on Responses of Rat Gracile Nucleus Neurons to Stimulation of Hindquarter Skin and Pelvic Viscera. Brain Res 986:82–90 Bradshaw HB, Temple JL, Wood E, Berkley KJ (1999) Estrous Variations in Behavioral Responses to Vaginal and Uterine Distention in the Rat. Pain 82:187–197 Cason AM, Samuelsen CL, Berkley KJ (2003) Estrous Changes in Vaginal Nociception in a Rat Model of Endometriosis. Horm Behav 44:123–131 Giamberardino MA, Berkley KJ, Affaitati G, Lerza R, Centurione L, Lapenna D, Vecchiet L (2002) Influence of Endometriosis on Pain Behaviors and Muscle Hyperalgesia Induced by a Ureteral Calculosis in Female Rats. Pain 95:247–257 Giamberardino MA, Valente R, de Bigontina P, Vecchiet L (1995) Artificial Ureteral Calculosis in Rats: Behavioural Characterization of Visceral Pain Episodes and their Relationship with Referred Lumbar Muscle Hyperalgesia. Pain 61:459–469 Gintzler AR, Komisaruk BR (1991) Analgesia is Produced by Uterocervical Mechanostimulation in Rats: Roles of Afferent Nerves and Implications for Analgesia of Pregnancy and Parturition. Brain Res 566:299–302 Sandner-Kiesling A, Pan HL, Chen SR, James RL, DeHaven-Hudkins DL, Dewan DM, Eisenach JC (2003) Effect of Kappa Opioid Agonists on Visceral Nociception Induced by Uterine Cervical Distension in Rats. Pain 96:13–22 Shin SW, Sandner-Kiesling A, Eisenach JC (2003) Systemic, but not Intrathecal Ketorolac is Antinociceptive to Uterine Cervical Distension in Rats. Pain 105:109–114 Temple JL, Bradshaw HB, Wood E, Berkley KJ (1999) Effects of Hypogastric Neurectomy on Escape Responses to Uterine Distention in the Rat. Pain Suppl 6:S13–S20 Tong C, Ma W, Shin SW, James RL, Eisenach JC (2003) Uterine Cervical Distension Induces cFos Expression in Deep Dorsal Horn Neurons of the Rat Spinal Cord. Anesthesiology 99:205–211 Vernon MW, Wilson EA (1985) Studies on the Surgical Induction of Endometriosis in the Rat. Fertil Steril 44:684–694 Wesselmann U, Czakanski PP, Affaitati G, Giamberardino MA (1998) Uterine Inflammation as a Noxious Visceral Stimulus: Behavioral Characterization in the Rat. Neurosci Lett 246:73–76 Wesselmann U, Lai J (1997) Mechanisms of Referred Visceral Pain: Uterine Inflammation in the Adult Virgin Rat Results in Neurogenic Plasma Extravasation in the Skin. Pain 73:309–317 Author information Authors and Affiliations Editor information Editors and Affiliations Rights and permissions Copyright information © 2007 Springer-Verlag Berlin Heidelberg About this entry Cite this entry Berkley, K. (2007). Visceral Pain Models, Female Reproductive Organ Pain. In: Schmidt, R., Willis, W. (eds) Encyclopedia of Pain. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-540-29805-2_4799 Download citation DOI: https://doi.org/10.1007/978-3-540-29805-2_4799 Publisher Name: Springer, Berlin, Heidelberg Print ISBN: 978-3-540-43957-8 Online ISBN: 978-3-540-29805-2 eBook Packages: MedicineReference Module Medicine