The incidence and characteristics of uterine bleeding during postoperative GnRH agonist treatment combined with tibolone add-back therapy in endometriosis patients of reproductive age

Soyoung Shin, So-Young Shin, Shin SY, Jung-Ae Min, Min JA, Yoon BK, Byung-Koo Yoon, Duk Soo Bae, Bae DS, Doo Seok Choi, Choi DS
European journal of obstetrics, gynecology, and reproductive biology · 2006 · vol. 133(1) , pp. 90–94 · doi:10.1016/j.ejogrb.2006.04.036 · PMID:16806656 · W2152201732
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This study investigated the occurrence and nature of uterine bleeding in reproductive-age endometriosis patients receiving postoperative GnRH agonist therapy alongside tibolone add-back treatment.

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Abstract

ObjectivesThis study was undertaken to evaluate the incidence and the factors associated with uterine bleeding while taking GnRH agonist treatment combined with tibolone add-back therapy in endometriosis patients of reproductive age.Study designThe medical records of 188 endometriosis (stages III-IV) patients of reproductive age receiving postoperative GnRH agonist treatment combined with tibolone add-back therapy for 6 months were reviewed. Clinical features were analyzed and compared between the two groups: Group A, patients without an episode of uterine bleeding (n=137) and Group B, patients that had experienced uterine bleeding (n=51).ResultsDemographic profiles were not different in the two groups. The incidence of uterine bleeding was 27.1% and irregular spotting was the most frequent bleeding pattern. The proportion of patients who received ovarian surgery during pelviscopy was higher in Group B (p<0.05), but other clinical characteristics were not different between two groups.ConclusionsThe incidence of uterine bleeding was 27.1%. And, the proportion of patients who received ovarian surgery was higher in patients with uterine bleeding.

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Condition tags

endometriosis

MeSH descriptors

Endometriosis Gonadotropin-Releasing Hormone Norpregnenes Postoperative Complications Uterine Hemorrhage Adult Drug Therapy, Combination Endometriosis Endometriosis Female Gonadotropin-Releasing Hormone Humans Incidence Norpregnenes Postoperative Complications Postoperative Complications Retrospective Studies Ultrasonography Uterine Hemorrhage Uterine Hemorrhage

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