Time-related effects of gonadotropin-releasing hormone analog treatment in experimentally induced endometriosis in the rat

Vanna Zanagnolo, Zanagnolo VL, V L Zanagnolo, Beck R, R. Beck, W D Schlaff, William D. Schlaff, Schlaff WD, Marian D. Damewood, Damewood MD, M D Damewood, Diana Bobbie, Bobbie D, D Bobbie, John A. Rock, J A Rock
Fertility and sterility · 1991 · vol. 55(2) , pp. 411–415 · doi:10.1016/s0015-0282(16)54137-5 · PMID:1991539 · W2401989034
article OA: closed CC0 ⤵ 10 in-corpus citations
🔓 Open OA copy View on OpenAlex View on PubMed View at publisher
⚙ AI-generated summary by gemini-2.5-flash-lite, 2026-07-09 ⓘ

Gonadotropin-releasing hormone analog treatment caused gradual regression of endometriosis explant in rats, with near-complete effects observed after 4 weeks.

One-sentence paraphrase of the abstract; not a substitute for reading it. No clinical advice. How this works

Abstract

The purpose of our study was to characterize the time-dependent effect of gonadotropin-releasing hormone analog (GnRH-a) therapy on endometriosis explant using the rat model. Endometriosis was induced in 60 mature female rats. One group of treated animals as well as controls were killed at 2, 4, 6 and 8 weeks of treatment at which time the explant was evaluated. Explant volume was significantly reduced in all treatment groups, an effect that was more significant in animals treated for greater than or equal to 4 weeks compared with those treated for only 2 weeks. We conclude that GnRH-a treatment caused gradual regression of endometrial explant that was effectively complete by 4 weeks of treatment. We further conclude that this experimental model may be useful in the evaluation of other modes of endometriosis therapy.

My notes (saved in your browser only)

Condition tags

endometriosis

MeSH descriptors

Endometriosis Gonadotropin-Releasing Hormone Triptorelin Pamoate Triptorelin Pamoate Analysis of Variance Animals Delayed-Action Preparations Disease Models, Animal Endometriosis Endometriosis Female Gonadotropin-Releasing Hormone Gonadotropin-Releasing Hormone Organ Culture Techniques Ovariectomy Rats Rats, Inbred Strains Reference Values Time Factors Uterus

Citation neighborhood

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

References (20)

Cited by (10)

Source provenance

europepmc
last seen: 2026-09-17T06:16:55.786923+00:00
openalex
last seen: 2026-06-10T17:14:06.276822+00:00
pubmed
last seen: 2026-05-13T22:12:00.397535+00:00
unpaywall
last seen: 2026-09-10T06:36:06.991349+00:00
License: CC0 · commercial use OK