Development of an animal model for quantitatively evaluating effects of drugs on endometriosis

Hahn DW, Do Won Hahn, D W Hahn, Carraher RP, Robert P. Carraher, R P Carraher, R G Foldesy, Robin G. Foldesy, Foldesy RG, McGuire JL, J L McGuire
Fertility and sterility · 1985 · vol. 44(3) , pp. 410–415 · doi:10.1016/s0015-0282(16)48869-2 · PMID:3896862 · W2233012768
article OA: closed CC0 ⤵ 14 in-corpus citations
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This study developed a mouse model to quantitatively assess how drugs impact endometriosis progression and lesion development.

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Abstract

The present study was conducted to induce endometriosis in an experimental animal model in which the condition and its response to pharmacologic agents could be quantified. Endometriosis was induced in New Zealand White rabbits by transplanting endometrial sections into various sites throughout the peritoneum. After 7 weeks, the mean implant weight increased in concomitant controls from 10.3 to 89.0 mg. In the next 8 weeks, endometrial implant weight increased to 163.6 mg. Daily subcutaneous administration of a luteinizing hormone-releasing hormone agonist, histrelin, or oral administration of danazol, reduced the ectopic implant weight within 8 weeks to 21.7 and 46.0 mg, respectively. In a group of animals that were bilaterally ovariectomized, implant weight decreased significantly in the same 8-week period to 22.4 mg. Furthermore, histologic analysis of the endometriomas showed that ovariectomy, histrelin, or danazol treatment reduced the number of endometrial glands and atrophied the stroma. We conclude that this animal model represents an excellent method for quantitative evaluation of potential therapeutic agents for endometriosis.

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Condition tags

endometriosis

MeSH descriptors

Disease Models, Animal Endometriosis Uterine Neoplasms Animals Castration Danazol Danazol Endometriosis Endometriosis Female Gonadotropin-Releasing Hormone Gonadotropin-Releasing Hormone Gonadotropin-Releasing Hormone Humans Luteinizing Hormone Luteinizing Hormone Neoplasms, Experimental Neoplasms, Experimental Neoplasms, Experimental Neoplasm Transplantation

Citation neighborhood

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

References (12)

Cited by (14)

SciLite annotations

organisms 3
rodents rodents multicellular animals
chemicals 2
danazol danazol

Source provenance

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