Hormonal effects of danazol and medical oophorectomy in endometriosis.
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Danazol suppressed estrogen to follicular phase levels and testosterone to levels that may inhibit endometrial proliferation, while GnRH-a caused greater estrogen suppression without androgenic effects.
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Abstract
The hormonal effects of danazol and of a long-acting gonadotropin-releasing hormone analogue (GnRH-a) were studied in women with endometriosis and those with oophorectomy. During danazol treatment, total serum concentrations of estrone and estradiol, and free, dialyzable estradiol were reduced to the low follicular phase range for premenopausal women. Corresponding estrogen levels were suppressed to a significantly greater degree (P less than .02) at the end of GnRH-a administration, to concentrations which were twofold to fourfold lower than with danazol therapy and similar to values in the oophorectomized women. Sex hormone binding globulin was markedly suppressed (P less than .001) throughout danazol treatment, resulting in a threefold elevation (P less than .01) of free testosterone. These data suggest that danazol may affect endometriosis by mechanisms other than by inducing a pseudomenopause. The increased tissue availability of testosterone may be responsible for acne and hirsutism observed in some women during danazol treatment and may inhibit proliferation of the ectopic endometrium. Medical oophorectomy using GnRH-a may have improved effects on endometriosis without the androgenic side effects of danazol.
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Cited by (22)
- Danazol regulates the functions of normal human endometrial stromal cell subpopulations by modifying endometrial cytokine networks 2009
- Therapeutic effects of leuprorelin microspheres on endometriosis and uterine leiomyomata 1997
- Vaginal patterns during danazol and buserelin acetate therapy for endometriosis: structural and ultrastructural study 1993
- Gonadotropin-releasing hormone agonists: Strategies formanaging the hypoestrogenic effects of therapy 1992
- Medical treatment of mild endometriosis associated with infertility 1991
- Medical treatment of endometriosis: a comparison of the suppressive effects of danazol and nafarelin on reproductive hormones 1991
- Cholesterol fractions and apolipoproteins during endometriosis treatment by a gonadotrophin releasing hormone (GnRH) agonist implant or by danazol 1991
- Effects of danazol, gonadotropin-releasing hormone agonist, and a combination of danazol and gonadotropin-releasing hormone agonist on experimental endometriosis 1990
- Comparison of Buserelin to Danazol Therapy in Endometriosis 1990
- Placebo-controlled comparison of hormonal and biochemical effects of danazol and high-dose medroxyprogesterone acetate 1990
- Comparison of Buserelin to Danazol Therapy in Endometriosis 1990
- GnRH Analogues in the Treatment of Endometriosis 1989
- Bone mineral density in women with endometriosis before and during ovarian suppression with gonadotropin-releasing hormone agonists or danazol 1988
- Treatment of Endometriosis by Nasal Administration of Nafarelin 1987
- DOSAGE‐RELATED EFFECTS OF DANAZOL ON SEX HORMONE BINDING GLOBULIN AND FREE AND TOTAL ANDROGEN LEVELS 1986
- Danazol inhibits steroidogenesis by the human ovary in vivo 1986
- Effects of progesterone, progestogens, and danazol on the specific cortisol binding in human plasma 1985
- Treatment of endometriosis with a potent agonist of gonadotropin-releasing hormone (nafarelin) 1985
- Development of an animal model for quantitatively evaluating effects of drugs on endometriosis 1985
- Gynecologic Problems of Adolescence 1985
- The influence of danazol on pituitary function and on the ovarian follicular hormone secretion in premenopausal women 1984
- Changes in the shbg concentration during danazol treatment 1984
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