GnRH Analogues in the Treatment of Endometriosis

Erickson LD, L D Erickson, Lisa D. Erickson, S J Ory, Steven J. Ory
Obstetrics and Gynecology Clinics of North America · 1989 · vol. 16(1) , pp. 123–145 · doi:10.1016/s0889-8545(21)00142-x · PMID:2526312 · W2444148625
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This paper reviews the current applications and emerging uses of gonadotropin-releasing hormone (GnRH) analogues in managing endometriosis symptoms and disease progression.

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Abstract

Modifications of the native gonadotropin-releasing hormone (GnRH) decapeptide have led to longer-acting compounds with increased binding ability. Pharmacologic doses of agonists result in suppression of ovarian estradiol production to levels similar to oophorectomized patients. The resultant hypoestrogenism is associated with regression in endometrial implant size. Both subjective and objective clinical improvement have been reported. Recent studies document that a reversible state of hypogonadism is effective treatment for endometriosis.

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Condition tags

endometriosis

MeSH descriptors

Endometriosis Pituitary Hormone-Releasing Hormones Buserelin Buserelin Danazol Danazol Endometriosis Female Gonadotropin-Releasing Hormone Gonadotropin-Releasing Hormone Gonadotropin-Releasing Hormone Humans Nafarelin Pituitary Hormone-Releasing Hormones

Citation neighborhood

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

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Cited by (20)

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License: CC0 · commercial use OK