Therapeutic hypogonadism induced by a delayed-release preparation of microcapsules of D-Trp-6-luteinizing hormone-releasing hormone: a preliminary study in eight women with endometriosis.
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A delayed-release D-Trp-6-LH-RH microcapsule preparation induced reversible hypogonadism in women with endometriosis, leading to clinical improvement despite side effects.
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Abstract
Eight menstrually cycling women with proven endometriosis were treated with a delayed-release preparation of the superactive agonist D-Trp-6-LH-RH in biodegradable microcapsules, administered intramuscularly at intervals of 16 to 36 days for a period of 3 to 5 months. After the first injection which caused a transient stimulatory response, a sustained hypogonadal state, characterized by an estradiol (E2) level less than 50 pg/mL, was induced in all patients by day +14.7 (range 7.19). Subsequent injections caused no more stimulation, but a continuous decrease in E2 levels was observed. In all patients, E2 levels fell to zero after the second or third injection. Gonadotropins remained in the normal range throughout the course of treatment. Hot flashes and severe dyspareunia (related to vaginal dryness) were the main side effects. Resumption of normal pituitary-ovarian activity was documented in all patients after the last injection; the end of the hypogonadal state, ovulation and menses, occurred on days 41 (range 32-59), 58 (range 51-64) and 70 (range 65-76), respectively. All patients showed a clinical improvement. Our results demonstrate that a long-lasting, reversible hypogonadism can be induced in cyclic women by intramuscular injections of D-Trp-6-LH-RH microcapsules at monthly intervals. This simple and convenient treatment should be useful in treating endometriosis and other conditions.
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Cited by (10)
- Equivalence of the 3-month and 28-day formulations of triptorelin with regard to achievement and maintenance of medical castration in women with endometriosis 2004
- Dienogest is as effective as triptorelin in the treatment of endometriosis after laparoscopic surgery: results of a prospective, multicenter, randomized study 2002
- LH-RH analogues: I. Their impact on reproductive medicine 1999
- Multiple gestation following gonadotrophin releasing hormone therapy for the treatment of minimal endometriosis 1994
- Long-term suppression of ovarian function by a luteinizing-hormone releasing hormone agonist implant in patients with endometriosis 1990
- Comparison of Buserelin to Danazol Therapy in Endometriosis 1990
- Basic and clinical aspects of GnRH‐agonists in reproduction 1990
- Comparison of Buserelin to Danazol Therapy in Endometriosis 1990
- GnRH Analogues in the Treatment of Endometriosis 1989
- Treatment of Endometriosis by Nasal Administration of Nafarelin 1987
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- europepmc
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- openalex
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- pubmed
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