LH-RH analogues: I. Their impact on reproductive medicine

Andrew V. Schally, A V Schally
Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology · 1999 · vol. 13(6) , pp. 401–409 · doi:10.3109/09513599909167587 · PMID:10685334 · W2065774213
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LH-RH analogues, including agonists and antagonists, have established diverse clinical applications in reproductive medicine by inhibiting the pituitary-gonadal axis.

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Abstract

In the 28 years that have passed since the elucidation of the structure of luteinizing hormone-releasing hormone (LH-RH), diverse clinical applications in the field of reproductive medicine and related fields have been established for agonists of LH-RH, based on inhibition of the pituitary-gonadal axis. Various clinical investigations with agonists of LH-RH in benign gynecologic disorders, polycystic ovary disease (PCOD), in vitro fertilization-embryo transfer (IVF-ET), benign prostatic hypertrophy (BPH), precocious puberty and contraception were reviewed. LH-RH antagonists inhibit LH, follicle-stimulating hormone (FSH), and sex steroid secretion immediately after their administration and thus achieve rapid therapeutic effects. LH-RH antagonists should find applications in the treatment of uterine leiomyomas, endometriosis, and in controlled ovarian stimulation-assisted reproductive techniques (COS-ART), which have been already established for the agonists. Modern LH-RH antagonists such as cetrorelix may prove superior to the agonists in COS-ART and also in the treatment of BPH, but additional studies in these and other areas are needed.

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Condition tags

endometriosis

MeSH descriptors

Gonadotropin-Releasing Hormone Reproductive Techniques Contraception Endometriosis Endometriosis Female Gonadotropin-Releasing Hormone Humans Male Polycystic Ovary Syndrome Polycystic Ovary Syndrome Prostatic Hyperplasia Prostatic Hyperplasia

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