Intranasal treatment with luteinising hormone releasing hormone agonist in women with endometriosis.
article
OA: bronze
CC0
⤵ 54 in-corpus citations
AI-generated summary
Intranasal buserelin effectively resolved endometriotic lesions in five of six women after six months, inducing anovulation and suppressing menstruation while relieving symptoms.
One-sentence paraphrase of the abstract; not a substitute for reading it. No clinical advice. How this works
Abstract
An agonist analogue of luteinising hormone releasing hormone (buserelin) was successfully used to treat women with endometriosis. A dose of 200 micrograms administered intranasally thrice daily was found to be effective in five patients, in whom the endometriotic lesions resolved after six months' treatment. Failure occurred in a sixth patient, who received only 400 micrograms once daily. Anovulation was induced in all subjects together with suppression of menstruation after the first month of treatment. Symptoms of abdominal pain, dysmenorrhoea, and dyspareunia were relieved during treatment, and one previously infertile patient conceived within two months of stopping treatment. No side effects were reported with this dosage, and the results suggest a new form of treatment for patients with endometriosis.
My notes (saved in your browser only)
Condition tags
MeSH descriptors
Citation neighborhood
Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.
References (13)
- Danazol: An antigonadotropic agent in the treatment of pelvic endometriosis via openalex
- Gonadotropin-Releasing Hormone Agonist Suppresses Ovulation, Menses, and Endometriosis in Monkeys: An Individualized, Intermittent Regimen* via openalex
- “MEDICAL OOPHORECTOMY” USING A LONG-ACTING GNRH AGONIST-A POSSIBLE NEW APPROACH TO THE TREATMENT OF ENDOMETRIOSIS. via openalex
- Potential new treatment of endometriosis: reversible inhibition of pituitary-ovarian function by chronic intranasal administration of a luteinizing hormone-releasing hormone (LH-RH) agonist via openalex
- Suggested Classification for Endometriosis: Relationship to Infertility via openalex
- The treatment of endometriosis with Danazol. via openalex
- The use of newer progestins in the treatment of endometriosis via openalex
- THE USE OF STILBESTROL FOR ENDOMETRIOSIS via openalex
- W2129737161 via openalex
- W2059961667 via openalex
- W2046432953 via openalex
- W2015817028 via openalex
- W2012521400 via openalex
Cited by (50)
- Gonadotropin-Releasing Hormone Agonists for Endometriosis 2008
- Is the endometriosis recurrence rate increased after ovarian hyperstimulation? 2006
- Cost comparisons between nafarelin and leuprolide in the treatment of endometriosis 1998
- Comparison of GnRH Agonist Administration Before and After Laparoscopic Drainage of Endometriomas 1997
- Ovarian endometrial cysts: the role of gonadotropin-releasing hormone agonist and/or drainage 1994
- Multiple gestation following gonadotrophin releasing hormone therapy for the treatment of minimal endometriosis 1994
- Medical management of endometriosis 1993
- Estrogenic suppression by different administration schedules of goserelin depot for treatment of endometriosis 1993
- Pretreatment with gonadotrophin releasing hormone (GnRH) analogue prior to in vitro fertilisation for patients with endometriosis 1993
- 7 Endometriosis and pelvic pain 1993
- Principles of medical therapy for endometriosis pain 1992
- Goserelin (Zoladex ) depot in the treatment of endometriosis 1992
- Endocrine Treatment of Endometriosis 1992
- Treatment of endometriosis 1992
- Endometriosetherapie mit Enantone®-Gyn Monats-Depot 1992
- Severe endometriosis treated with gonadotrophin releasing hormone agonist and continuous combined hormone replacement therapy 1992
- Endometriosis and adenomyosis 1991
- A Comparative Treatment Trial of Endometriosis Using the Gonadotrophin‐releasing Hormone Agonist, Nafarelin, and the Synthetic Steroid, Danazol 1991
- The endometrium and endometriosis 1991
- Medical treatment of mild endometriosis associated with infertility 1991
- GnRH analogues in the treatment of endometriosis — rationale and efficacy 1991
- Comparison of Buserelin to Danazol Therapy in Endometriosis 1990
- Lupron depot (leuprolide acetate for depot suspension) in the treatment of endometriosis: a randomized, placebo-controlled, double-blind study 1990
- Comparison of Buserelin to Danazol Therapy in Endometriosis 1990
- The Use of GnRH Analogues to Control Menstrual Bleeding 1990
- Gonadotropin-releasing hormone analogs in the treatment of endometriomas 1990
- Long-term suppression of ovarian function by a luteinizing-hormone releasing hormone agonist implant in patients with endometriosis 1990
- Basic and clinical aspects of GnRH‐agonists in reproduction 1990
- Buserelin 1990
- A comparison of nafarelin acetate and danazol in the treatment of endometriosis 1990
- The Use of GnRH Analogues to Control Menstrual Bleeding 1990
- Buserelin versus danazol in the treatment of endometriosis-associated infertility 1989
- Endometriosis: treatment with gonadotropin-releasing hormone agonist Buserelin 1989
- GnRH Analogues in the Treatment of Endometriosis 1989
- Efficacy Of Gonadotropin‐Releasing Hormone Agonist (Buserelin) in The Treatment Of Endometriosis 1989
- A NEW TREATMENT FOR ENDOMETRIOSIS 1989
- LH-RH agonist (Buserelin): treatment of endometriosis 1989
- 10 LHRH analogues in the treatment of endometriosis—comparative results with other treatments 1988
- Prevention of follicular maturation in endometriosis by subcutaneous infusion of luteinizing hormone-releasing hormone agonist started in the luteal phase 1988
- Perspectives for the Clinical Use of Aromatase Inhibitors 1988
- Administration of Nasal Nafarelin as Compared with Oral Danazol for Endometriosis 1988
- Clinicai applications of GnRH analogs 1988
- GnRH agonists—antagonists — clinical applications 1988
- Treatment of Endometriosis by Nasal Administration of Nafarelin 1987
- Endometriosis 1987
- Impact of gestrinone on the course of asymptomatic endometriosis. 1987
- Pharmacokinetics, Metabolism and Clinical Studies with Buserlin 1987
- Treatment with a luteinising hormone-releasing hormone analogue (Buserelin) in danazol-resistant endometriosis patients 1986
- Treatment of Endometriosis in Monkeys: Effectiveness of Continuous Infusion of a Gonadotropin-Releasing Hormone Agonist Compared to Treatment with a Progestational Steroid* 1986
- Studies Utilizing a Luteinizing-Hormone-Releasing Hormone Agonist in the Therapy of Endometriosis 1986
Source provenance
- europepmc
- last seen: 2026-06-11T06:19:48.454388+00:00
- openalex
- last seen: 2026-06-10T17:14:06.276822+00:00
- pubmed
- last seen: 2026-05-13T22:09:55.985569+00:00
License: CC0
· commercial use OK