Endometriosis: treatment with gonadotropin-releasing hormone agonist Buserelin

A M Franssen, Anton M.H.W. Franssen, Franssen AM, Frank M. Kauer, Kauer Fm, F M Kauer, Dev R. Chadha, D R Chadha, Chadha DR, Jeanette A. Zijlstra, Zijlstra Ja, J A Zijlstra, Rolland R, R. Rolland
Fertility and sterility · 1989 · vol. 51(3) , pp. 401–408 · doi:10.1016/s0015-0282(16)60544-7 · PMID:2522063 · W2399012703
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This paper details the treatment of endometriosis using the gonadotropin-releasing hormone agonist, Buserelin.

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Abstract

Fifty-one women with pelvic endometriosis were treated with the gonadotropin-releasing hormone agonist (GnRHa) Buserelin (Hoechst Holland N.V., Amsterdam, The Netherlands) 300 micrograms three times a day intranasally for 6 months. Forty-nine women completed treatment; 42 were available for 6 months of follow-up following treatment. Symptoms showed prompt and significant improvement. Follow-up after treatment revealed persistent relief from dysmenorrhea and dyspareunia in, respectively, 58.6% and 88.2% of the women, whereas pelvic pain returned to pretreatment scores. Serum estradiol (E2) was suppressed to predominantly early follicular phase concentrations. Laparoscopy at the end of therapy showed significant reduction of scores for implants only. There was no relation between the degree of E2 suppression during therapy and the improvement of symptoms or the reduction of endometriosis. Statistical analysis in 22 infertile patients, of whom 7 conceived during follow-up, revealed no differences in E2 levels during therapy, improvement of symptoms, or reduction of endometriosis. Buserelin appears to be safe, well tolerated, and effective in the management of endometriosis and associated complaints.

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Condition tags

dysmenorrheaendometriosis

MeSH descriptors

Buserelin Endometriosis Pelvic Neoplasms Adult Buserelin Buserelin Dysmenorrhea Dysmenorrhea Dysmenorrhea Endometriosis Endometriosis Endometriosis Female Follow-Up Studies Hormones Hormones Humans Infertility, Female Infertility, Female Infertility, Female

Citation neighborhood

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

References (26)

Cited by (27)

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License: CC0 · commercial use OK