Buserelin acetate in the treatment of pelvic pain associated with minimal and mild endometriosis: a controlled study

Fedele L, Luigi Fedele, L Fedele, Bianchi S, S Bianchi, Stefano Bianchi, Luca Bocciolone, L Bocciolone, Di Nola G, Giuliana Di Nola, G Di Nola, D. Franchi, Franchi D
Fertility and sterility · 1993 · vol. 59(3) , pp. 516–521 · doi:10.1016/s0015-0282(16)55792-6 · PMID:8458450 · W2418234085
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This controlled study investigated the efficacy of buserelin acetate in treating pelvic pain in women with minimal and mild endometriosis.

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Abstract

ObjectiveTo evaluate the changes of pain symptoms induced by buserelin acetate, a gonadotropin-releasing hormone agonist, in a group of patients with endometriosis.DesignThirty-five infertile patients with one or more of the following symptoms (dysmenorrhea, pelvic pain, deep dyspareunia, and endometriosis stage I or II) were allocated randomly to treatment with buserelin acetate 1,200 micrograms/d IN for 6 months (n = 19) or expectant management (n = 16). Pain symptoms were recorded by the women themselves using a questionnaire that included two scales for pain evaluation: one analogue and one multidimensional. The treated and untreated patients were followed for a minimum of 18 and 12 months from the time of randomization, respectively.ResultsBuserelin acetate markedly reduced dysmenorrhea, pelvic pain, and dyspareunia during the treatment and also for the 12 subsequent months. During follow-up of the expectant management group, dysmenorrhea resolved in 19% (3/16) of the cases, and pelvic pain did not recur after diagnostic laparoscopy in one of the three women affected nor did deep dyspareunia in two of the five who reported the symptom before laparoscopy.ConclusionBuserelin acetate induced a significant improvement of pain symptoms that persisted in approximately half of the patients even after withdrawal of the drug. However, symptoms associated with endometriosis showed a spontaneous remission in approximately one fifth of the untreated patients.

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Condition tags

dysmenorrheaendometriosis

MeSH descriptors

Buserelin Endometriosis Pain Buserelin Dysmenorrhea Dysmenorrhea Endometriosis Endometriosis Female Humans Pain Pelvis

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