Goserelin (Zoladex ) depot in the treatment of endometriosis

Romeo P. Reichel, R. Reichel, Karl-Werner Schweppe, Karl-W. Schweppe, Zoladex Endometriosis Study Group
Fertility and sterility · 1992 · vol. 57(6) , pp. 1197–1202 · doi:10.1016/s0015-0282(16)55073-0 · W166103824
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This paper investigates the efficacy of goserelin depot injections in treating endometriosis symptoms and reports its effects.

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Abstract

Study objectiveTo evaluate the safety and efficacy of Goserelin (Zoladex depot; ICI Pharmaceuticals, Macclesfield, Cheshire, United Kingdom) in the treatment of endometriosis.DesignOpen study.SettingEleven centers in Germany and 1 center in Austria.PatientsOne hundred forty-six patients with pelvic endometriosis.InterventionGoserelin (Zoladex depot) therapy, one depot (3.6 mg) subcutaneously every 4 weeks for 6 months.ResultsTotal subjective score and total pelvic symptom score showed a reduction by 86% and 93%, respectively, at the end of the treatment and did not exceed one fifth of the pretreatment value throughout the follow-up period of 48 weeks. One hundred seven women underwent a second laparoscopy at the end of the therapy for determination of objective efficacy: 54% of the patients showed a reduction of implants and adhesions by at least 50% or more, and 31.5% had a complete resolution of visible deposits. The mean reduction of implants and adhesions was 50%, and the mean reduction of implants 72%. Twenty of 64 (31.3%) previously infertile patients successfully conceived within 12 months after discontinuation of the therapy. Goserelin led to a down regulation of the pituitary ovarian axis and as a pharmacological effect of this hypoestrogenism most patients had hot flushes and vaginal dryness.ConclusionsZoladex depot therapy proved to be safe and effective in the medical treatment of endometriosis.

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endometriosis

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