Serum estradiol and danazol. I. Endometriosis response, side effects, administration interval, concurrent spironolactone and dexamethasone

Richard P. Dickey, R P Dickey, Dickey Rp, Taylor SN, S N Taylor, Steven N. Taylor, Curole DN, D N Curole, David N. Curole
Fertility and sterility · 1984 · vol. 42(5) , pp. 709–716 · doi:10.1016/s0015-0282(16)48195-1 · PMID:6489545 · W2223316669
article OA: closed CC0 ⤵ 14 in-corpus citations
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⚙ AI-generated summary by claude@2026-06, 2026-06-20 ⓘ

This study investigated the effects of serum estradiol and danazol on endometriosis response, side effects, administration interval, and concurrent use of spironolactone and dexamethasone.

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Abstract

Serum estradiol (E2) levels and resolution of endometriosis were evaluated in 42 women after 75 days of danazol treatment. Complete or almost complete remission occurred when radioimmunoassay E2 levels were less than 15 pg/ml in extensive, less than 22 pg/ml in severe, and less than 41 pg/ml in moderate endometriosis. E2 less than or equal to 20 pg/ml occurred in 23% of 104 patients given 400 mg every 12 hours but in none weighing over 150 pounds (68 kg). E2 greater than 100 pg/ml occurred in 7%. The mean E2 levels were identical with 400 mg every 12 hours and 200 mg every 8 hours. The E2 level was 40% lower with 200 mg every 6 hours than with 400 mg every 12 hours (P less than 0.001). Dexamethasone further decreased E2 levels by 61% (P less than 0.001). Spironolactone decreased androgen symptoms but increased E2 levels by 49% (P less than 0.01).

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Condition tags

endometriosis

MeSH descriptors

Danazol Dexamethasone Endometriosis Estradiol Pelvic Neoplasms Pregnadienes Spironolactone Adult Age Factors Body Weight Danazol Danazol Dexamethasone Dexamethasone Drug Administration Schedule Drug Therapy, Combination Endometriosis Endometriosis Estradiol Female

Citation neighborhood

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

References (25)

Cited by (14)

SciLite annotations

chemicals 9
estradiol danazol spironolactone dexamethasone estradiol danazol dexamethasone spironolactone androgen

Source provenance

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License: CC0 · commercial use OK