Sex steroid levels during treatment of endometriosis.
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This study observed marked increases in serum estradiol and testosterone levels during danazol treatment for endometriosis, while FSH, LH, and prolactin remained unaffected.
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Abstract
Ovarian endocrine function in endometriosis was studied in 19 women before, during, and after treatment with danazol. Striking abnormalities were seen during treatment. Serum estradiol (E2) and testosterone (T) levels increased markedly, while follicle-stimulating hormone (FSH), luteinizing hormone (LH), and prolactin were unaffected. Direct interference of danazol in the assays for E2 and T was excluded by in vitro experiments. The most likely explanation for the isolated alterations in peripheral hormone levels is that danazol affects the carrier proteins in the circulation. However, other explanations are also possible and cannot be excluded at this stage.
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Cited by (16)
- Danazol regulates the functions of normal human endometrial stromal cell subpopulations by modifying endometrial cytokine networks 2009
- Danazol enhances Fas-mediated apoptosis in human endometrial epithelial cells within normal physiology 1998
- Adrenal Steroids in Serum during Danazol Therapy, Taking into Account Cross-Reactions between Danazol Metabolites and Serum Androgens. 1993
- Effects of danazol, gonadotropin-releasing hormone agonist, and a combination of danazol and gonadotropin-releasing hormone agonist on experimental endometriosis 1990
- Relationship of gonadotropin-releasing hormone, danazol, and prostaglandin blockade to ovarian enlargement and ascites formation of the ovarian hyperstimulation syndrome in the rabbit 1986
- DOSAGE‐RELATED EFFECTS OF DANAZOL ON SEX HORMONE BINDING GLOBULIN AND FREE AND TOTAL ANDROGEN LEVELS 1986
- Serum estradiol and danazol. I. Endometriosis response, side effects, administration interval, concurrent spironolactone and dexamethasone 1985
- Postoperative danazol therapy in infertility patients with severe endometriosis 1985
- Serum estradiol and danazol. I. Endometriosis response, side effects, administration interval, concurrent spironolactone and dexamethasone 1984
- Dynamic tests of hypothalamic and pituitary function in women treated with danazol 1982
- Danazol: Endocrine consequences in healthy women 1981
- Danazol and uterine leiomyomas. 1981
- Danazol and Thyroid Function 1980
- Endometriosis--continuing conundrum. 1980
- Endometriosis—continuing conundrum 1980
- Danazol and Thyroid Function 1979
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- europepmc
- last seen: 2026-09-06T09:34:12.023084+00:00
- openalex
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- pubmed
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