Danazol and uterine leiomyomas.

Yuen Bh
In: Can Med Assoc J · 1981 · vol. 124(8) , pp. 963–4 · W1527332509
article OA: green CC0
🔓 Open OA copy Full text JSON View on OpenAlex
⚙ AI-generated summary by claude@2026-06+body, 2026-06-07 ⓘ

This paper discusses the endocrine properties and clinical application of danazol, referencing its inhibitory effects on steroidogenesis and impact on sex steroid levels.

One-sentence paraphrase of the abstract; not a substitute for reading it. No clinical advice. How this works

⚙ AI-generated deep summary by claude@2026-06, 2026-06-07 · read from full text ⓘ

This paper reviews the relationship between danazol treatment and uterine leiomyomas, focusing on what danazol does in the context of abnormal uterine smooth muscle growth. It draws on prior work describing danazol’s endocrine effects, including inhibition of steroidogenesis and changes in sex-steroid levels used in hormone suppression for gynecologic conditions, and connects these biochemical actions to leiomyoma-related considerations. A key caveat implied by the presentation is that the discussion relies on cited prior studies rather than providing new primary clinical data within the paper itself. Relevance to endometriosis: the paper cites studies of danazol’s effects on sex steroid levels during treatment of endometriosis, though its main focus is uterine leiomyomas.

Read from the paper's body, not the abstract. Not a substitute for reading the paper. No clinical advice. How this works

Full text 1,302 characters · extracted from oa-html · click to expand
Full text PDFSelected References These references are in PubMed. This may not be the complete list of references from this article. - Barbieri R. L., Canick J. A., Makris A., Todd R. B., Davies I. J., Ryan K. J. Danazol inhibits steroidogenesis. Fertil Steril. 1977 Aug;28(8):809–813. [PubMed] [Google Scholar] - Dmowski W. P. Endocrine properties and clinical application of danazol. Fertil Steril. 1979 Mar;31(3):237–251. doi: 10.1016/s0015-0282(16)43869-0. [DOI] [PubMed] [Google Scholar] - Hirschowitz J. S., Soler N. G., Wortsman J. Sex steroid levels during treatment of endometriosis. Obstet Gynecol. 1979 Oct;54(4):448–450. [PubMed] [Google Scholar] - Rannevik G. Hormonal, metabolic and clinical effects of danazol in the treatment of endometriosis. Postgrad Med J. 1979;55 (Suppl 5):14–20. [PubMed] [Google Scholar] - Reddy V. V., Rose L. I. delta 4-3-Ketosteroid 5 alpha-oxidoreductase in human uterine leiomyoma. Am J Obstet Gynecol. 1979 Oct 1;135(3):415–418. doi: 10.1016/0002-9378(79)90716-6. [DOI] [PubMed] [Google Scholar] - Tsang B. K., Henderson K. M., Armstrong D. T. Effect of danazol on estradiol-17beta and progesterone secretion by porcine ovarian cells in vitro. Am J Obstet Gynecol. 1979 Feb 1;133(3):256–259. doi: 10.1016/0002-9378(79)90675-6. [DOI] [PubMed] [Google Scholar]

Text is read by the "Ask this paper" AI Q&A widget below. Extraction quality varies by source — PMC NXML preserves structure cleanly, OA-HTML may include some navigation residue, and OA-PDF can have broken hyphenation. The publisher copy is the canonical version.

My notes (saved in your browser only)

⚙ Ask this paper AI returns verbatim quotes from the full text · source: oa-html ⓘ

Answers must be backed by verbatim quotes from this paper's full text. Hallucinated quotes are dropped automatically; if no verbatim passage answers the question, we say so. How this works

Citation neighborhood (sparse)

Too few in-corpus citations on either side for a chart; here are the lists.

Cites (4)

References (6)

Source provenance

openalex
last seen: 2026-05-10T10:04:54.844167+00:00
License: CC0 · commercial use OK