Danazol and Thyroid Function

Letters and Corrections1 January 1980Danazol and Thyroid FunctionROBERT L. BARBIERI, M.D.ROBERT L. BARBIERI, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-92-1-133_2 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: In a recent issue Wortsman and associates (1) reported that women receiving 400 to 800 mg of danazol daily have a low thyroxine (T4) index and normal thyrotropin (TSH) levels. They concluded that some women receiving danazol might be hypothyroid. Their observations do not support their conclusion. Detailed analysis of the effects of danazol on thyroid function indices has shown that danazol lowers thyroxine-binding globulin (TBG) capacity, lowers total T4, and produces no change in free T4(hence the normal TSH) (2). One explanation of these thyroid function indices is that the androgenic effects of danazol result...References1. WORTSMANHIRSCHOWITZSOLER JJN. Danazol and thyroid function. Ann Intern Med. 1979;91:321. Letter. LinkGoogle Scholar2. PANNALLMAAS PD. Danazol and thyroid-function tests. Lancet. 1977;1:102. Letter. CrossrefMedlineGoogle Scholar1. TOFTSETHHUNTERIRVINE AJWW. Plasma thyrotrophin and serum thyroxine in patients becoming hypothyroid in the early months after iodine-131. Lancet. 1974;1:704-5. CrossrefMedlineGoogle Scholar2. FLEISHERMCCONAHEYPANKOW GWM. Serum creatine kinase, lactic dehydrogenase, and glutamic-oxalacetic transaminase in thyroid diseases and pregnancy. Mayo Clin Proc. 1965;40:300-11. MedlineGoogle Scholar3. SCARPALEZOSLYGIDAKISPAPAGEORGIOUMALIARAKOUKOULOMMATIKOUTRAS SCCSAD. Neural and muscular manifestations of hypothyroidism. Arch Neurol. 1973;29:140-4. CrossrefMedlineGoogle Scholar4. GOLDMANMATXMORTIMERFREEMAN JRRR. High elevations of creatine phosphokinase in hypothyroidism. JAMA. 1977;238:325-6. CrossrefMedlineGoogle Scholar5. HIRSCHOWITZSOLERWORTSMAN JNJ. Sex steroid levels during treatment of endometriosis. Obstet Gynecol. 1979;54:448-50. MedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Peter Bent Brigham Hospital Boston, MA 02115 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByThe use of danazol as a treatment of endometriosisDanazol: Endocrine pharmacology and therapeutic applications 1 January 1980Volume 92, Issue 1Page: 133-134KeywordsGlobulinsThyroidThyroid-stimulating hormoneThyroxine Issue Published: 1 January 1980 PDF DownloadLoading ...