Danazol and Thyroid Function

Letters1 August 1979Danazol and Thyroid FunctionJACOBO WORTSMAN, M.D., JACK HIRSCHOWITZ, M.D., NORMAN SOLER, M.D.JACOBO WORTSMAN, M.D.Search for more papers by this author, JACK HIRSCHOWITZ, M.D.Search for more papers by this author, NORMAN SOLER, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-91-2-321_1 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: Dr. Spaulding has reported in the May 1979 issue (1) a patient with hereditary angioedema who developed a rise in the level of creatine phosphokinase during treatment with danazol. We have recently reported our experience with this drug in 19 patients with endometriosis (2) but our total experience to date covers 27 patients. When using danazol in doses ranging from 400 to 800 mg daily, clinically significant side-effects were few and affected only three women. One patient developed severe acne, another a transient rash, and a third patient complained of hot flashes and a decrease in the...References1. SPAULDING W. Myalgia and elevated creatine phosphokinase with Danazol® in hereditary angioedema. Ann Intern Med. 1979;90:854. Letter. LinkGoogle Scholar2. HIRSCHOWITZSOLERWORTSMAN JNJ. Sex steroid levels during treatment of endometriosis. Obstet Gynecol. 1979. In press. MedlineGoogle Scholar3. HIRSCHOWITZSOLERWORTSMAN JNJ The galactorrhea-endometriosis syndrome. Lancet. 1970;1:896-8. Google Scholar4. POTTS G. Pharmacology of danazol. J Int Med Res. 1977; 5(suppl 3):1-14. MedlineGoogle Scholar5. GOLDMANMATZMORTIMERFREEMAN JRRR. High elevations of creatine phosphokinase in hypothyroidism. An isoenzyme analysis. JAMA. 1977;238:325-6. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: JACOBO WORTSMAN, M.D.; JACK HIRSCHOWITZ, M.D.; NORMAN SOLER, M.D.Affiliations: Southern Illinois University School of Medicine Springfield, IL 62708 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byDanazol and Thyroid FunctionROBERT L. BARBIERI, M.D. 1 August 1979Volume 91, Issue 2Page: 321-321KeywordsAcneCreatineDrugsHereditary angioedemaRashesThyroid ePublished: 1 December 2008 Issue Published: 1 August 1979 PDF downloadLoading ...