Myalgia and Elevated Creatine Phosphokinase with Danazol® in Hereditary Angioedema

Letters and Corrections1 May 1979Myalgia and Elevated Creatine Phosphokinase with Danazol® in Hereditary AngioedemaWILLIAM B. SPAULDING, M.D.WILLIAM B. SPAULDING, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-90-5-854_2 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: Danazol®, a synthetic steroid that inhibits pituitary gonadotropins (1), is effective in preventing attacks of hereditary angioedema (2). Side effects are minor, the commonest being menstrual irregularities or amenorrhea, weight gain, edema, and acne (3). Muscle aching has been mentioned without reference to the plasma level of creatine phosphokinase (CPK) (3, 4). The following summary describes the case of a patient with hereditary angioedema whose attacks stopped when she took Danazol but who had muscle cramps and aching with elevated CPK levels until Danazol was withdrawn.The patient, a 40-year-old woman, began to have bouts of abdominal...References1. POTTS G: Pharmacology of danazol. J Int Med Res 5(suppl 3):1-14, 1977 MedlineGoogle Scholar2. GELFANDSHERINSALLINGFRANK JRDM: Treatment of hereditary angioedema with danazol. Reversal of clinical and biochemical abnormalities. N Engl J Med 295:1444-1448, 1976 CrossrefMedlineGoogle Scholar3. YOUNGBLACKMORE MW: The use of danazol in the management of endometriosis. J Int Med Res 5(suppl 3):86-91, 1977 MedlineGoogle Scholar4. SPOONER J: Classification of side-effects to danazol therapy. J Int Med Res 5 (suppl 3):15-17, 1977 MedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: McMaster University Hamilton, ON L8S 4J9, Canada PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited by10 Introduction to the toxicology of muscleRace-gender differences in serum creatine kinase activity: a study among South Africans.Danazol treatment increases serum enzyme levelsThe Enzymology of Skeletal Muscle DisordersDanazol and Thyroid FunctionJACOBO WORTSMAN, M.D., JACK HIRSCHOWITZ, M.D., NORMAN SOLER, M.D. 1 May 1979Volume 90, Issue 5Page: 854-854KeywordsAcneBlood plasmaCreatineCreatinine phosphokinaseEdemaGonadotropinsHereditary angioedemaMusclesMyalgiaWeight gain Issue Published: 1 May 1979 PDF downloadLoading ...