Relationship of gonadotropin-releasing hormone, danazol, and prostaglandin blockade to ovarian enlargement and ascites formation of the ovarian hyperstimulation syndrome in the rabbit

S M Pride; Sheila M. Pride; Basil Ho Yuen; B H Yuen; Young Soo Moon; Y S Moon; Peter C. K. Leung; P C Leung

doi:10.1016/0002-9378(86)90778-7

Relationship of gonadotropin-releasing hormone, danazol, and prostaglandin blockade to ovarian enlargement and ascites formation of the ovarian hyperstimulation syndrome in the rabbit

S M Pride, Sheila M. Pride, Basil Ho Yuen, B H Yuen, Young Soo Moon, Y S Moon, Peter C. K. Leung, P C Leung

American journal of obstetrics and gynecology · 1986 · vol. 154(5) , pp. 1155–1160 · doi:10.1016/0002-9378(86)90778-7 · PMID:3085504 · W2071134370

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Pharmacologic doses of gonadotropin-releasing hormone, danazol, and indomethacin did not suppress ovarian enlargement and ascites formation in rabbits hyperstimulated with gonadotropins.

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Abstract

The effects of pharmacologic doses of gonadotropin-releasing hormone, danazol, and indomethacin on the clinical and endocrinologic features of the ovarian hyperstimulation syndrome were studied in the rabbit. The ovarian hyperstimulation syndrome was induced with Pergonal (75 IU of follicle-stimulating hormone and 75 IU of luteinizing hormone) and a follicle-stimulating hormone-dominant gonadotropin preparation (85 IU of follicle-stimulating hormone and 53 IU of luteinizing hormone). None of the three agents tested were effective in suppressing the ovarian enlargement and ascites formation in these animals. Ascites developed despite quite significant variations in plasma and intraovarian sex steroid hormone and intraovarian prostaglandin F levels induced by danazol and indomethacin. Ascites develops in hyperstimulated women in association with both follicular and luteal hyperstimulation. In contrast, the ascites response in the hyperstimulated rabbit develops in the presence of follicular hyperstimulation alone without a significant degree of luteal hyperstimulation.

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MeSH descriptors

Danazol Indomethacin Ovarian Diseases Ovary Ovulation Induction Pituitary Hormone-Releasing Hormones Pregnadienes Animals Ascites Ascites Danazol Female Follicle Stimulating Hormone Indomethacin Luteinizing Hormone Menotropins Ovarian Diseases Ovarian Diseases Ovarian Follicle Ovarian Follicle

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Cites (3)

Cited by (1)

Elevated interleukin-6 levels in the ovarian hyperstimulation syndrome: ovarian immunohistochemical localization of interleukin-6 signal 1996

References (14)

Competitive inhibition by danazol of oestradiol binding to rabbit and ovine uterine oestradiol receptor via openalex
Danazol Inhibits Steroidogenesis via openalex
Sex steroid levels during treatment of endometriosis via openalex
doi:10.1016/s0002-9378(16)33605-5 via openalex
doi:10.1016/s0015-0282(16)43508-9 via openalex
doi:10.1210/endo-106-6-1697 via openalex
doi:10.1016/s0015-0282(16)37032-7 via openalex
doi:10.1016/0014-2999(80)90443-4 via openalex
doi:10.1016/0090-6980(72)90062-7 via openalex
doi:10.1016/s0015-0282(16)41780-2 via openalex
doi:10.1016/0002-9378(81)90611-6 via openalex
doi:10.1016/0028-2243(76)90001-0 via openalex
doi:10.1016/0002-9378(84)90771-3 via openalex
doi:10.1210/endo-107-2-407 via openalex

Cited by (1)

Elevated interleukin-6 levels in the ovarian hyperstimulation syndrome: ovarian immunohistochemical localization of interleukin-6 signal 1996

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[1] Danazol Inhibits Steroidogenesis 1977

[2] Sex steroid levels during treatment of endometriosis 1979

[3] Competitive inhibition by danazol of oestradiol binding to rabbit and ovine uterine oestradiol receptor 1980