Danazol has progestin-like actions on the human endometrium
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Abstract
The administration of danazol, 200 mg three times daily, from the 3rd to the 23rd day of the cycle to normally menstruating women exhibited the following actions on the human endometrium: significantly reduced cytosol oestrogen and progestin receptor concentrations, and declined 17 beta-hydroxysteroid dehydrogenase activity. Very similar results were obtained during medroxyprogesterone acetate (100 mg daily) treatment for the same period of time. Danazol administration did not decrease circulating gonadotrophin levels but clearly suppressed luteal serum oestradiol and progesterone concentrations. Danazol was found to bind in vitro to endometrial progestin receptor with an affinity approximately 3% of that of progesterone. These findings are compatible with the notion that a local progestin-like rather than a systemic action of danazol is the way by which its therapeutic effect is exerted. This may be potentiated by the suppression of circulating oestradiol levels.
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- Effects of danazol and progesterone on sex hormone-binding globulin mRNA expression in human endometrial cancer cell line Ishikawa 1997
- MODERN MEDICAL MANAGEMENT OF ENDOMETRIOSIS 1997
- Postmenopausal endometrial hyperplasia: role of danazol therapy 1994
- Action of danazol on the conversion of estrone sulfate to estradiol and on the sulfatase activity in the MCF-7, T-47D and MDA-MB-231 human mammary cancer cells 1993
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- Endometrial patterns during therapy with danazol or gestrinone for endometriosis: Structural and ultrastructural study 1992
- Endometrial Effects of Danazol in Perimenopausal Abnormal Bleeding 1991
- Endometrial patterns during danazol and cyproterone acetate treatment for endometriosis: structural and ultrastructural study 1991
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- Effects of danazol, gonadotropin-releasing hormone agonist, and a combination of danazol and gonadotropin-releasing hormone agonist on experimental endometriosis 1990
- STEROIDAL DRUGS IN ENDOMETRIOSIS 1989
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- Genital Bleeding during the Administration of Danazol 1988
- Placebo-controlled comparison of danazol and high-dose medroxyprogesterone acetate in the treatment of endometriosis 1987
- Growth inhibition by danazol in a human endometrial cancer cell line with estrogen-independent progesterone receptors 1987
- Effects of danazol on incidence of progesterone and oestrogen receptors in benign breast disease. 1987
- Effect of progestins, androgens, estrogens and antiestrogens on3H-thymidine uptake by human endometrial and endosalpinx cells in vitro 1987
- Placebo-controlled comparison of danazol and high-dose medroxypro-gesterone acetate in the treatment of endometriosis after conservative surgery 1987
- Danazol binds to progesterone receptors and inhibits the growth of human endometrial cancer cells in vitro 1986
- Steroidal regulation of endometriosis tissue: lack of induction of 17β-hydroxysteroid dehydrogenase activity by progesterone, medroxyprogesterone acetate, or danazol 1985
- Short‐term effects of danazol and medroxyprogesterone acetate on cytosol and nuclear estrogen and progestin receptors, 17β‐hydroxysteroid dehydrogenase activity, histopathology, and ultrastructure of human endometrial adenocarcinoma 1985
- Serum estradiol and danazol. I. Endometriosis response, side effects, administration interval, concurrent spironolactone and dexamethasone 1985
- Serum estradiol and danazol. I. Endometriosis response, side effects, administration interval, concurrent spironolactone and dexamethasone 1984
- Short‐term effects of danazol on endometrial histology 1984
- Cytosol estrogen and progestin receptor concentrations and 17β‐hydroxysteroid dehydrogenase activities in the endometrium and endometriotic tissue 1984
- Progestin-Like Effects of Danazol on Rabbit Uterus* 1983
- Estrogen and progestin receptors in endometriosis lesions: Comparison with endometrial tissue 1981
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- last seen: 2026-05-10T10:24:49.251717+00:00
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