Endometrial patterns during danazol and cyproterone acetate treatment for endometriosis: structural and ultrastructural study

M Marchini, Maurizio Marchini, Marchini M, L Fedele, Luigi Fedele, Stefano Bianchi, S Bianchi, Luisa Arcaini, Arcaini L, L Arcaini, Diana Brioschi, D Brioschi, Brioschi D, Giuliana Di Nola, Di Nola G, G Di Nola
European journal of obstetrics, gynecology, and reproductive biology · 1991 · vol. 40(2) , pp. 137–143 · doi:10.1016/0028-2243(91)90105-t · PMID:1830018 · W2019902002
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⚙ AI-generated summary by claude@2026-06, 2026-06-08 ⓘ

This study investigated and compared the structural and ultrastructural changes in endometrial tissue of patients treated with danazol and cyproterone acetate for endometriosis.

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Abstract

We studied the endometrial structure and ultrastructure in serial biopsies from 16 patients with endometriosis treated with danazol (n = 9) or the combination cyproterone acetate plus ethinyl estradiol (n = 7) for 6 months. Biopsies were performed before and at 3 and 6 months of treatment. The material obtained was studied by light (LM), scanning (SEM) and transmission electron microscopy (TEM). A morphometric analysis was performed evaluating three morphometric and three stereologic indices. The results indicate that danazol had a progestational effect on endometrial glands and stroma, associated with a marked hypotrophy of the mucosa. The cyproterone acetate/ethinyl estradiol combination induced progressive atrophy of the endometrium with an increase in the stromal component and a reduction of glandular tissue.

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Condition tags

endometriosis

MeSH descriptors

Cyproterone Danazol Endometriosis Endometrium Ethinyl Estradiol Adult Biopsy Cyproterone Cyproterone Cyproterone Cyproterone Acetate Danazol Drug Combinations Endometriosis Endometriosis Endometrium Endometrium Endometrium Estradiol Estradiol

Citation neighborhood

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References (18)

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Source provenance

europepmc
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