Endometrial patterns during danazol and cyproterone acetate treatment for endometriosis: structural and ultrastructural study

M Marchini, Maurizio Marchini, Marchini M, L Fedele, Luigi Fedele, Stefano Bianchi, S Bianchi, Luisa Arcaini, Arcaini L, L Arcaini, Diana Brioschi, D Brioschi, Brioschi D, Giuliana Di Nola, Di Nola G, G Di Nola
European journal of obstetrics, gynecology, and reproductive biology · 1991 · vol. 40(2) , pp. 137–143 · doi:10.1016/0028-2243(91)90105-t · PMID:1830018 · W2019902002
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This study investigated and compared the structural and ultrastructural changes in endometrial tissue of patients treated with danazol and cyproterone acetate for endometriosis.

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Abstract

We studied the endometrial structure and ultrastructure in serial biopsies from 16 patients with endometriosis treated with danazol (n = 9) or the combination cyproterone acetate plus ethinyl estradiol (n = 7) for 6 months. Biopsies were performed before and at 3 and 6 months of treatment. The material obtained was studied by light (LM), scanning (SEM) and transmission electron microscopy (TEM). A morphometric analysis was performed evaluating three morphometric and three stereologic indices. The results indicate that danazol had a progestational effect on endometrial glands and stroma, associated with a marked hypotrophy of the mucosa. The cyproterone acetate/ethinyl estradiol combination induced progressive atrophy of the endometrium with an increase in the stromal component and a reduction of glandular tissue.

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Condition tags

endometriosis

MeSH descriptors

Cyproterone Danazol Endometriosis Endometrium Ethinyl Estradiol Adult Adult Biopsy Biopsy Cyproterone Cyproterone Cyproterone Cyproterone Cyproterone Acetate Cyproterone Acetate Danazol Danazol Drug Combinations Drug Combinations Endometriosis

Citation neighborhood (2-hop)

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. Outer rings show 2-hop neighbours — papers reached through the immediate citers/citees. [ collapse to 1-hop ]

References (18)

Cited by (5)

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