Comparison of different treatment modalities of endometriosis in infertile women.

M E Hull, K S Moghissi, David F. Magyar, D F Magyar, Maria F. Hayes, M F Hayes
Fertility and Sterility · 1987 · vol. 16(1) , pp. 236–4 · PMID:2947817 · W2056817030
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This study compared no treatment, medroxyprogesterone acetate, and danazol for endometriosis in infertile women, finding no significant differences in pregnancy rates or abortion rates among the groups.

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Abstract

This study was designed to evaluate the effectiveness of three therapeutic modalities in the management of stage I and II endometriosis. Management modalities consisted of no treatment (controls, n = 56); oral medroxyprogesterone acetate (MPA), 30 mg orally per day for 90 days (n = 36); and danazol, 600 to 800 mg daily for 6 months (n = 52). All patients were followed for at least 18 months of exposure to pregnancy. Cumulative pregnancy rates were determined by life-table analysis. At 30 months, pregnancies resulted in 55% of group I (controls), 71% of group II (MPA), and 46% of group III (danazol). There were no significant differences among these rates. Similarly, there was no significant difference between the cumulative pregnancy rates for stage I (59%) and for stage II (57%). Abortion rates for the various treatment modalities were the following: MPA 6.3%, danazol 11%, and no treatment, 14.3%. The spontaneous abortion rate in stage I and stage II disease was not significantly different. The results of this study suggest that a period of expectant management with correction of other infertility factors may be warranted in patients with mild to moderate endometriosis before medical therapy is contemplated.

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Condition tags

mesh:D004715endometriosisinfertility

MeSH descriptors

Danazol Endometriosis Infertility, Female Medroxyprogesterone Pelvic Neoplasms Pregnadienes Adult Antineoplastic Agents Antineoplastic Agents Danazol Endometriosis Endometriosis Female Follow-Up Studies Humans Infertility, Female Infertility, Female Medroxyprogesterone Medroxyprogesterone Medroxyprogesterone Acetate

Citation neighborhood

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

References (12)

Cited by (50)

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