Postmenopausal endometrial hyperplasia: role of danazol therapy

Luigi Mariani, A. Sedati, R. Giovinazzi, R Sindico, G Atlante
In: International Journal of Gynecology & Obstetrics · 1994 · vol. 44(2) , pp. 155–159 · doi:10.1016/0020-7292(94)90071-x · PMID:7911101 · W2047091979
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Danazol therapy effectively treated postmenopausal endometrial hyperplasia in 82.8% of patients, resolving uterine bleeding in 90% of responders, despite some relapses and persistent hyperplasia.

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Abstract

OBJECTIVES: To confirm the effectiveness of danazol in the management of simple or complex endometrial hyperplasia without atypical features, as has been demonstrated previously. METHODS: Seventy-six patients affected by postmenopausal histologically-confirmed endometrial hyperplasia with uterine bleeding were submitted to danazol therapy at a dose of 400 mg/day for 3 consecutive months. RESULTS: After cessation of treatment, 82.8% of the patients (63/76 enrolled) showed a conversion of the hyperplasia into atrophic (65.8%), secretory (11.9%) or proliferative (4.2%) endometrium at the histological examination. Uterine bleeding disappeared, during the therapy, in 90% of the responders (59/63). CONCLUSIONS: Although 17.1% of the women had a persistence of the hyperplasia and 8.4% of the symptom-free women relapsed after 4 months of follow-up, this experience confirms the effectiveness of danazol therapy in hyperplastic endometrial lesions. Nevertheless, a study comparing danazol and progestin therapy is required.

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