Postmenopausal endometrial hyperplasia: role of danazol therapy

L Mariani, Luigi Mariani, A. Sedati, R. Giovinazzi, R Sindico, G Atlante
International Journal of Gynecology & Obstetrics · 1994 · vol. 44(2) , pp. 155–159 · doi:10.1016/0020-7292(94)90071-x · PMID:7911101 · W2047091979
Non-randomised trial OA: closed CC0 ⤵ 3 in-corpus citations
View on OpenAlex View on PubMed View at publisher
⚙ AI-generated summary by gemini-2.5-flash-lite, 2026-06-08 ⓘ

Danazol therapy effectively treated postmenopausal endometrial hyperplasia in 82.8% of patients, resolving uterine bleeding in 90% of responders, despite some relapses and persistent hyperplasia.

One-sentence paraphrase of the abstract; not a substitute for reading it. No clinical advice. How this works

Abstract

OBJECTIVES: To confirm the effectiveness of danazol in the management of simple or complex endometrial hyperplasia without atypical features, as has been demonstrated previously. METHODS: Seventy-six patients affected by postmenopausal histologically-confirmed endometrial hyperplasia with uterine bleeding were submitted to danazol therapy at a dose of 400 mg/day for 3 consecutive months. RESULTS: After cessation of treatment, 82.8% of the patients (63/76 enrolled) showed a conversion of the hyperplasia into atrophic (65.8%), secretory (11.9%) or proliferative (4.2%) endometrium at the histological examination. Uterine bleeding disappeared, during the therapy, in 90% of the responders (59/63). CONCLUSIONS: Although 17.1% of the women had a persistence of the hyperplasia and 8.4% of the symptom-free women relapsed after 4 months of follow-up, this experience confirms the effectiveness of danazol therapy in hyperplastic endometrial lesions. Nevertheless, a study comparing danazol and progestin therapy is required.

My notes (saved in your browser only)

MeSH descriptors

Danazol Endometrial Hyperplasia Postmenopause Aged Danazol Endometrial Hyperplasia Endometrial Hyperplasia Endometrium Endometrium Female Follow-Up Studies Humans Middle Aged Recurrence

Citation neighborhood (2-hop)

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. Outer rings show 2-hop neighbours — papers reached through the immediate citers/citees. [ collapse to 1-hop ]

References (26)

Cited by (3)

Source provenance

openalex
last seen: 2026-06-04T00:00:01.174412+00:00
pubmed
last seen: 2026-10-08T21:59:07.256998+00:00
unpaywall
last seen: 2026-10-14T06:23:58.021457+00:00
License: CC0 · commercial use OK