Genital Bleeding during the Administration of Danazol

Gen‐ichi Nakamura, G Nakamura, Kiyotaka Yoshimitsu, K Yoshimitsu, Mutsunori Imura, M Imura, Hitoo Nakano, H Nakano
Asia-Oceania journal of obstetrics and gynaecology · 1988 · vol. 14(3) , pp. 373–377 · doi:10.1111/j.1447-0756.1988.tb00119.x · PMID:3178583 · W2080756422
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Starting danazol treatment on the first or second day of the menstrual cycle significantly reduced genital bleeding and increased amenorrhea compared to later initiation in women with endometriosis.

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Abstract

Abstract In an effort to reduce undesirable bleeding during danazol treatment, we attempted to see any correlation between the frequency of bleeding and the starting period of danazol treatment during the menstrual cycle. We studied 57 women who were suffering from endometriosis externa and given danazol (400 mg/day) for periods between 16 and 24 weeks. The patients were divided into 4 groups depending on the day administration of the drug began; 18 patients started on the 1st or 2nd day of the menstrual cycle, 12 on the 3rd day, 20 on the 5th day and 7 after the 10th day. The rate of bleeding was 6.8±6.3% (M±SD) in the group starting on the 1st or 2nd day. This was significantly smaller than that of other groups starting treatment later in the menstrual cycle. The number of patients with complete amenorrhea throughout the entire treatment period was significantly higher in the group beginning administration of danazol on the 1st or 2nd day of the menstrual cycle. Therefore, administration of danazol should be started as early as possible in the menstrual cycle to reduce the frequency of bleeding.

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Condition tags

endometriosis

MeSH descriptors

Danazol Endometriosis Genital Neoplasms, Female Pregnadienes Uterine Hemorrhage Adult Danazol Danazol Endometriosis Female Genital Neoplasms, Female Humans Pregnadienes Uterine Hemorrhage

Citation neighborhood

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References (11)

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